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Literature summary extracted from

  • Haaz, M.C.; Fischel, J.L.; Formento, P.; Renee, N.; Etienne, M.C.; Milano, G.
    Impact of different fluorouracil biochemical modulators on cellular dihydropyrimidine dehydrogenase (1996), Cancer Chemother. Pharmacol., 38, 52-58.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.1 allopurinol cell lines CAL 27, CAL 51, ORL 1, PANC 3 Homo sapiens
1.3.1.1 cisplatin cell line ORL 1 Homo sapiens
1.3.1.2 allopurinol cell lines CAL 27, CAL 51, ORL 1, PANC 3 Homo sapiens
1.3.1.2 cisplatin cell line ORL 1 Homo sapiens

Application

EC Number Application Comment Organism
1.3.1.1 medicine target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate Homo sapiens
1.3.1.2 medicine target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.1 cisplatin cell lines CAL 27, CAL 33, CAL 51, PANC 3 Homo sapiens
1.3.1.1 dipyridamole cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3, mechanism Homo sapiens
1.3.1.1 Hydroxyurea cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3 Homo sapiens
1.3.1.2 cisplatin cell lines CAL 27, CAL 33, CAL 51, PANC 3 Homo sapiens
1.3.1.2 dipyridamole cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3, mechanism Homo sapiens
1.3.1.2 Hydroxyurea cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.1 5-fluorouracil + NADPH + H+ Homo sapiens
-
 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 5-fluorouracil + NADPH + H+ Homo sapiens
-
 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.1 Homo sapiens
-
-
-
1.3.1.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.1 CAL-27 cell
-
 Homo sapiens
-
1.3.1.1 CAL-33 cell
-
 Homo sapiens
-
1.3.1.1 CAL-51 cell
-
 Homo sapiens
-
1.3.1.1 carcinoma cell cell line ORL 1 Homo sapiens
-
1.3.1.1 PANC-3 cell
-
 Homo sapiens
-
1.3.1.2 CAL-27 cell
-
 Homo sapiens
-
1.3.1.2 CAL-33 cell
-
 Homo sapiens
-
1.3.1.2 CAL-51 cell
-
 Homo sapiens
-
1.3.1.2 carcinoma cell cancer cell line ORL 1 Homo sapiens
-
1.3.1.2 PANC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.1 5-fluorouracil + NADPH + H+
-
 Homo sapiens 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?
1.3.1.2 5-fluorouracil + NADPH + H+
-
 Homo sapiens 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.1 DPD
-
 Homo sapiens