BRENDA - Enzyme Database

Impact of different fluorouracil biochemical modulators on cellular dihydropyrimidine dehydrogenase

Haaz, M.C.; Fischel, J.L.; Formento, P.; Renee, N.; Etienne, M.C.; Milano, G.; Cancer Chemother. Pharmacol. 38, 52-58 (1996)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.3.1.1
allopurinol
cell lines CAL 27, CAL 51, ORL 1, PANC 3
Homo sapiens
1.3.1.1
cisplatin
cell line ORL 1
Homo sapiens
1.3.1.2
allopurinol
cell lines CAL 27, CAL 51, ORL 1, PANC 3
Homo sapiens
1.3.1.2
cisplatin
cell line ORL 1
Homo sapiens
Application
EC Number
Application
Commentary
Organism
1.3.1.1
medicine
target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate
Homo sapiens
1.3.1.2
medicine
target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.3.1.1
cisplatin
cell lines CAL 27, CAL 33, CAL 51, PANC 3
Homo sapiens
1.3.1.1
dipyridamole
cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3, mechanism
Homo sapiens
1.3.1.1
Hydroxyurea
cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3
Homo sapiens
1.3.1.2
cisplatin
cell lines CAL 27, CAL 33, CAL 51, PANC 3
Homo sapiens
1.3.1.2
dipyridamole
cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3, mechanism
Homo sapiens
1.3.1.2
Hydroxyurea
cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.3.1.1
5-fluorouracil + NADPH
Homo sapiens
-
5-fluoro-5,6-dihydrouracil + NADP+
-
Homo sapiens
?
1.3.1.2
5-fluorouracil + NADPH
Homo sapiens
-
5-fluoro-5,6-dihydrouracil + NADP+
-
Homo sapiens
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.3.1.1
Homo sapiens
-
-
-
1.3.1.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.3.1.1
CAL-27 cell
-
Homo sapiens
-
1.3.1.1
CAL-33 cell
-
Homo sapiens
-
1.3.1.1
CAL-51 cell
-
Homo sapiens
-
1.3.1.1
carcinoma cell
cell line ORL 1
Homo sapiens
-
1.3.1.1
PANC-3 cell
-
Homo sapiens
-
1.3.1.2
CAL-27 cell
-
Homo sapiens
-
1.3.1.2
CAL-33 cell
-
Homo sapiens
-
1.3.1.2
CAL-51 cell
-
Homo sapiens
-
1.3.1.2
carcinoma cell
cancer cell line ORL 1
Homo sapiens
-
1.3.1.2
PANC-3 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.3.1.1
5-fluorouracil + NADPH
-
349142
Homo sapiens
5-fluoro-5,6-dihydrouracil + NADP+
-
349142
Homo sapiens
?
1.3.1.2
5-fluorouracil + NADPH
-
349142
Homo sapiens
5-fluoro-5,6-dihydrouracil + NADP+
-
349142
Homo sapiens
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.3.1.1
allopurinol
cell lines CAL 27, CAL 51, ORL 1, PANC 3
Homo sapiens
1.3.1.1
cisplatin
cell line ORL 1
Homo sapiens
1.3.1.2
allopurinol
cell lines CAL 27, CAL 51, ORL 1, PANC 3
Homo sapiens
1.3.1.2
cisplatin
cell line ORL 1
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
1.3.1.1
medicine
target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate
Homo sapiens
1.3.1.2
medicine
target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.3.1.1
cisplatin
cell lines CAL 27, CAL 33, CAL 51, PANC 3
Homo sapiens
1.3.1.1
dipyridamole
cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3, mechanism
Homo sapiens
1.3.1.1
Hydroxyurea
cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3
Homo sapiens
1.3.1.2
cisplatin
cell lines CAL 27, CAL 33, CAL 51, PANC 3
Homo sapiens
1.3.1.2
dipyridamole
cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3, mechanism
Homo sapiens
1.3.1.2
Hydroxyurea
cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.3.1.1
5-fluorouracil + NADPH
Homo sapiens
-
5-fluoro-5,6-dihydrouracil + NADP+
-
Homo sapiens
?
1.3.1.2
5-fluorouracil + NADPH
Homo sapiens
-
5-fluoro-5,6-dihydrouracil + NADP+
-
Homo sapiens
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.3.1.1
CAL-27 cell
-
Homo sapiens
-
1.3.1.1
CAL-33 cell
-
Homo sapiens
-
1.3.1.1
CAL-51 cell
-
Homo sapiens
-
1.3.1.1
carcinoma cell
cell line ORL 1
Homo sapiens
-
1.3.1.1
PANC-3 cell
-
Homo sapiens
-
1.3.1.2
CAL-27 cell
-
Homo sapiens
-
1.3.1.2
CAL-33 cell
-
Homo sapiens
-
1.3.1.2
CAL-51 cell
-
Homo sapiens
-
1.3.1.2
carcinoma cell
cancer cell line ORL 1
Homo sapiens
-
1.3.1.2
PANC-3 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.3.1.1
5-fluorouracil + NADPH
-
349142
Homo sapiens
5-fluoro-5,6-dihydrouracil + NADP+
-
349142
Homo sapiens
?
1.3.1.2
5-fluorouracil + NADPH
-
349142
Homo sapiens
5-fluoro-5,6-dihydrouracil + NADP+
-
349142
Homo sapiens
?