EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | thiamine diphosphate | - |
Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.2.4.4 | - |
Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.2.4.4 | S293A | mutation in the alpha-subunit, nearly 12fold increase in Km-value, no inactivation after incubation with ATP | Rattus norvegicus |
1.2.4.4 | S293E | mutation in the alpha-subunit, completely inactive enzyme | Rattus norvegicus |
1.2.4.4 | S293E/S303E | mutation in the alpha-subunit, no activity | Rattus norvegicus |
1.2.4.4 | S303A | mutation in the alpha-subunit, no effect upon enzyme activity | Rattus norvegicus |
1.2.4.4 | S303E | mutation in the alpha-subunit, no effect upon enzyme activity | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | ATP | time-dependent inactivation of wild-type enzyme and mutant proteins S303A, S303E, with mutation in the alpha-subunit | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.4.4 | 160000 | - |
wild-type enzyme and mutant enzymes S293E, S293A, S303A and S293E/S303E, gel filtration | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.4.4 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.4.4 | - |
Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | CoA | - |
Rattus norvegicus | |
1.2.4.4 | NAD+ | - |
Rattus norvegicus |