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Literature summary extracted from

  • Dickinson, J.R.
    Branched-chain keto acid dehydrogenase of yeast (2000), Methods Enzymol., 324, 389-398.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.4.4 thiamine diphosphate
-
Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.4.4 Tris
-
Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.4.4 0.0075
-
2-oxobutanoate
-
Saccharomyces cerevisiae
1.2.4.4 0.0133
-
2-oxo-4-methylthiobutanoate
-
Saccharomyces cerevisiae
1.2.4.4 0.0199
-
3-methyl-2-oxopentanoate
-
Saccharomyces cerevisiae
1.2.4.4 0.0218
-
4-methyl-2-oxopentanoate
-
Saccharomyces cerevisiae
1.2.4.4 0.213
-
3-methyl-2-oxobutanoate
-
Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.4.4 38000
-
alphax,betax, x * 478000 + x * 38000, SDS-PAGE Saccharomyces cerevisiae
1.2.4.4 478000
-
alphax,betax, x * 478000 + x * 38000, SDS-PAGE Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.4 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.4.4
-
Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.4.4 0.82
-
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.4.4 2-oxo-4-methylthiobutanoate + NAD+ + CoA 38% of the activity with 3-methyl-2-oxobutanoate Saccharomyces cerevisiae 3-methylthiopropionyl-CoA + NADH + CO2
-
?
1.2.4.4 2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 20% of the activity with 3-methyl-2-oxobutanoate Saccharomyces cerevisiae [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(propanoyl)dihydrolipoyllysine + CO2
-
?
1.2.4.4 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Saccharomyces cerevisiae [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?
1.2.4.4 3-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 38% of the activity with 3-methyl-2-oxobutanoate Saccharomyces cerevisiae [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2
-
?
1.2.4.4 4-methyl-2-oxopentanoate + NAD+ + CoA 38% of the activity with 3-methyl-2-oxobutanoate Saccharomyces cerevisiae 3-methylbutanoyl-CoA + CO2 + NADH
-
?

Subunits

EC Number Subunits Comment Organism
1.2.4.4 ? alphax,betax, x * 478000 + x * 38000, SDS-PAGE Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.4.4 7.5
-
-
Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.4.4 CoA extraordinarily tightly bound Saccharomyces cerevisiae
1.2.4.4 NAD+
-
Saccharomyces cerevisiae