EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | thiamine diphosphate | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.4.4 | 0.0258 | - |
2-oxobutanoate | - |
Rattus norvegicus | |
1.2.4.4 | 0.82 | - |
pyruvate | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.4.4 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | additional information | Rattus norvegicus | the intramitochondrial pyruvate dehydrogenase complex and the branched-chain 2-oxo acid dehydrogenase complex are responsible for the oxidative decarboxylation of 2-oxobutanoate, the branched-chain 2-oxo acid dehydrogenase complex is probably the more important complex | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.4.4 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.4.4 | heart | - |
Rattus norvegicus | - |
1.2.4.4 | kidney | - |
Rattus norvegicus | - |
1.2.4.4 | liver | - |
Rattus norvegicus | - |
1.2.4.4 | muscle | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | 2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(propanoyl)dihydrolipoyllysine + CO2 | - |
? | |
1.2.4.4 | 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 | - |
? | |
1.2.4.4 | additional information | the intramitochondrial pyruvate dehydrogenase complex and the branched-chain 2-oxo acid dehydrogenase complex are responsible for the oxidative decarboxylation of 2-oxobutanoate, the branched-chain 2-oxo acid dehydrogenase complex is probably the more important complex | Rattus norvegicus | ? | - |
? | |
1.2.4.4 | pyruvate + NAD+ + CoA | - |
Rattus norvegicus | acetyl-CoA + CO2 + NADH | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | CoA | - |
Rattus norvegicus | |
1.2.4.4 | NAD+ | - |
Rattus norvegicus |