EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | thiamine diphosphate | - |
Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | 2-chloroisocaproate | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.4.4 | 0.01 | - |
3-methyl-2-oxopentanoate | - |
Rattus norvegicus | |
1.2.4.4 | 0.011 | - |
4-methyl-2-oxopentanoate | - |
Rattus norvegicus | |
1.2.4.4 | 0.011 | - |
3-methyl-2-oxobutanoate | - |
Rattus norvegicus | |
1.2.4.4 | 2.2 | - |
pyruvate | - |
Rattus norvegicus | |
1.2.4.4 | 2.5 | - |
2-oxoglutarate | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.8.1.4 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.4.4 | additional information | - |
MW of the multienzyme complex is 2000000 Da, determined by sucrose density gradient centrifugation | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.4.4 | Rattus norvegicus | - |
- |
- |
1.8.1.4 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.4.4 | multienzyme complex | Rattus norvegicus |
1.8.1.4 | dissociation of the lipoamide dehydrogenase component from the branched-chain alpha-keto acid dehydrogenase complex during purification | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.4.4 | liver | - |
Rattus norvegicus | - |
1.2.4.4 | muscle | - |
Rattus norvegicus | - |
1.8.1.4 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.8.1.4 | 133 | - |
- |
Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | 2-oxoglutarate + NAD+ + CoA | - |
Rattus norvegicus | 3-carboxypropionyl-CoA + NADH + CO2 | - |
? | |
1.2.4.4 | 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 | - |
? | |
1.2.4.4 | 3-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2 | - |
? | |
1.2.4.4 | 4-methyl-2-oxopentanoate + NAD+ + CoA | - |
Rattus norvegicus | 3-methylbutanoyl-CoA + CO2 + NADH | - |
? | |
1.2.4.4 | pyruvate + NAD+ + CoA | - |
Rattus norvegicus | acetyl-CoA + CO2 + NADH | - |
? | |
1.8.1.4 | dihydrolipoamide + NAD+ | - |
Rattus norvegicus | lipoamide + NADH | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | CoA | - |
Rattus norvegicus | |
1.2.4.4 | NAD+ | - |
Rattus norvegicus | |
1.8.1.4 | NAD+ | - |
Rattus norvegicus |