EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | thiamine diphosphate | - |
Oryctolagus cuniculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.4 | 2-Chloroisohexanoate | - |
Bos taurus | |
2.7.11.4 | 2-Chloroisohexanoate | - |
Oryctolagus cuniculus | |
2.7.11.4 | 2-Chloroisohexanoate | - |
Rattus norvegicus | |
2.7.11.4 | 2-oxo-3-methylpentanoate | - |
Oryctolagus cuniculus | |
2.7.11.4 | 2-oxo-3-methylpentanoate | - |
Rattus norvegicus | |
2.7.11.4 | 2-oxobutanoate | - |
Oryctolagus cuniculus | |
2.7.11.4 | 2-oxohexanedioate | - |
Bos taurus | |
2.7.11.4 | 2-oxohexanedioate | - |
Oryctolagus cuniculus | |
2.7.11.4 | 2-oxohexanedioate | - |
Rattus norvegicus | |
2.7.11.4 | 2-Oxohexanoate | - |
Oryctolagus cuniculus | |
2.7.11.4 | 2-oxoisocaproate | - |
Bos taurus | |
2.7.11.4 | 2-oxoisocaproate | - |
Oryctolagus cuniculus | |
2.7.11.4 | 2-oxoisocaproate | - |
Rattus norvegicus | |
2.7.11.4 | 2-oxoisopentanoate | - |
Oryctolagus cuniculus | |
2.7.11.4 | 2-oxoisopentanoate | - |
Rattus norvegicus | |
2.7.11.4 | 2-oxopentanoate | - |
Bos taurus | |
2.7.11.4 | 2-oxopentanoate | - |
Oryctolagus cuniculus | |
2.7.11.4 | 4-hydroxyphenylpyruvate | - |
Oryctolagus cuniculus | |
2.7.11.4 | acetoacetyl-CoA | - |
Bos taurus | |
2.7.11.4 | acetoacetyl-CoA | - |
Oryctolagus cuniculus | |
2.7.11.4 | acetoacetyl-CoA | - |
Rattus norvegicus | |
2.7.11.4 | ADP | - |
Bos taurus | |
2.7.11.4 | ADP | competitive | Oryctolagus cuniculus | |
2.7.11.4 | ADP | - |
Rattus norvegicus | |
2.7.11.4 | Ca2+ | weak | Oryctolagus cuniculus | |
2.7.11.4 | Clofibric acid | - |
Oryctolagus cuniculus | |
2.7.11.4 | Dichloroacetate | - |
Oryctolagus cuniculus | |
2.7.11.4 | Dichloroacetate | - |
Rattus norvegicus | |
2.7.11.4 | heparin | - |
Oryctolagus cuniculus | |
2.7.11.4 | isobutyryl-CoA | - |
Oryctolagus cuniculus | |
2.7.11.4 | isovaleryl-CoA | - |
Oryctolagus cuniculus | |
2.7.11.4 | malonyl-CoA | - |
Oryctolagus cuniculus | |
2.7.11.4 | methylmalonyl-CoA | - |
Bos taurus | |
2.7.11.4 | methylmalonyl-CoA | - |
Oryctolagus cuniculus | |
2.7.11.4 | methylmalonyl-CoA | - |
Rattus norvegicus | |
2.7.11.4 | Mg2+ | at concentrations above 1.5 mM, activation below | Oryctolagus cuniculus | |
2.7.11.4 | n-Octanoate | - |
Bos taurus | |
2.7.11.4 | n-Octanoate | - |
Oryctolagus cuniculus | |
2.7.11.4 | n-Octanoate | - |
Rattus norvegicus | |
2.7.11.4 | NADP+ | - |
Oryctolagus cuniculus | |
2.7.11.4 | phenylacetate | - |
Oryctolagus cuniculus | |
2.7.11.4 | Phenyllactate | - |
Oryctolagus cuniculus | |
2.7.11.4 | pyruvate | - |
Oryctolagus cuniculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.11.4 | 0.025 | - |
ATP | pH 7.35, 20°C | Oryctolagus cuniculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.11.4 | mitochondrion | part of intramitochondrial branched-chain 2-oxoacid dehydrogenase complex | Rattus norvegicus | 5739 | - |
2.7.11.4 | mitochondrion | part of intramitochondrial branched-chain 2-oxoacid dehydrogenase complex | Bos taurus | 5739 | - |
2.7.11.4 | mitochondrion | part of intramitochondrial branched-chain 2-oxoacid dehydrogenase complex | Oryctolagus cuniculus | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.4 | EGTA | activation, presumably by chelation of Ca2+ | Oryctolagus cuniculus | |
2.7.11.4 | Mg2+ | - |
Rattus norvegicus | |
2.7.11.4 | Mg2+ | - |
Bos taurus | |
2.7.11.4 | Mg2+ | maximum activity at 1.5 mM, inhibits above 1.5 mM | Oryctolagus cuniculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.11.4 | 2000000 | - |
above 2000000, gel filtration | Oryctolagus cuniculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Rattus norvegicus | phosphorylation inactivates EC 1.2.4.4 | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Bos taurus | phosphorylation inactivates EC 1.2.4.4 | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Oryctolagus cuniculus | phosphorylation inactivates EC 1.2.4.4 | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.4.4 | Oryctolagus cuniculus | - |
- |
- |
2.7.11.4 | Bos taurus | - |
- |
- |
2.7.11.4 | Oryctolagus cuniculus | - |
- |
- |
2.7.11.4 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.11.4 | - |
Rattus norvegicus |
2.7.11.4 | alpha-ketoacid dehydrogenase complex | Oryctolagus cuniculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.4.4 | liver | - |
Oryctolagus cuniculus | - |
2.7.11.4 | brain | - |
Oryctolagus cuniculus | - |
2.7.11.4 | heart | - |
Rattus norvegicus | - |
2.7.11.4 | kidney | - |
Rattus norvegicus | - |
2.7.11.4 | kidney | - |
Bos taurus | - |
2.7.11.4 | kidney | cortex | Oryctolagus cuniculus | - |
2.7.11.4 | liver | - |
Rattus norvegicus | - |
2.7.11.4 | liver | - |
Bos taurus | - |
2.7.11.4 | liver | - |
Oryctolagus cuniculus | - |
2.7.11.4 | skeletal muscle | - |
Rattus norvegicus | - |
2.7.11.4 | skeletal muscle | - |
Oryctolagus cuniculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | 2-oxo-4-methylthiobutanoate + NAD+ + CoA | - |
Oryctolagus cuniculus | 3-methylthiopropionyl-CoA + NADH + CO2 | - |
? | |
1.2.4.4 | 2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Oryctolagus cuniculus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(propanoyl)dihydrolipoyllysine + CO2 | - |
? | |
1.2.4.4 | 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Oryctolagus cuniculus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 | - |
? | |
1.2.4.4 | 3-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Oryctolagus cuniculus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2 | - |
? | |
1.2.4.4 | 4-methyl-2-oxopentanoate + NAD+ + CoA | - |
Oryctolagus cuniculus | 3-methylbutanoyl-CoA + CO2 + NADH | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | 2 Ser-residues in E1-alpha-subunit | Rattus norvegicus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | 2 Ser-residues in E1-alpha-subunit | Bos taurus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | 2 Ser-residues in E1-alpha-subunit | Oryctolagus cuniculus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | incorporates 0.75 mol phosphate per mol phosphorylation site and 1.5 mol/mol alpha-subunit | Oryctolagus cuniculus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | phosphorylation inactivates EC 1.2.4.4 | Rattus norvegicus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | phosphorylation inactivates EC 1.2.4.4 | Bos taurus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | phosphorylation inactivates EC 1.2.4.4 | Oryctolagus cuniculus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.11.4 | additional information | - |
in decreasing order of activity: HEPES, potassium phosphate, imidazole, 3-(N-morpholino)ethane buffer | Oryctolagus cuniculus |
2.7.11.4 | 7.5 | - |
- |
Oryctolagus cuniculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | CoA | - |
Oryctolagus cuniculus | |
1.2.4.4 | NAD+ | - |
Oryctolagus cuniculus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.11.4 | 0.13 | - |
ADP | pH 7.35, 20°C | Oryctolagus cuniculus |