EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | alpha-Chloroisocaproate | activation of the enzyme complex in intact cell and tissue preparations | Rattus norvegicus | |
1.2.4.4 | thiamine diphosphate | - |
Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.4 | 2-Chloroisohexanoate | no inhibition by (R)(-)-2-chloroisopentanoate; potassium phosphate increases sensitivity to this inhibitor | Oryctolagus cuniculus | |
2.7.11.4 | 2-Chloroisohexanoate | no inhibition by (R)(-)-2-chloroisopentanoate; potassium phosphate increases sensitivity to this inhibitor; (R)(+)-isomer is twice as effective as (S)(-)-isomer; site-specific inhibitor | Rattus norvegicus | |
2.7.11.4 | 2-oxo-3-methylpentanoate | more effective than 2-oxoisopentanoate | Oryctolagus cuniculus | |
2.7.11.4 | 2-oxo-3-methylpentanoate | more effective than 2-oxoisopentanoate | Rattus norvegicus | |
2.7.11.4 | 2-oxoisocaproate | more effective than 2-oxo-3-methylpentanoate and 2-oxoisopentanoate | Oryctolagus cuniculus | |
2.7.11.4 | 2-oxoisocaproate | more effective than 2-oxo-3-methylpentanoate and 2-oxoisopentanoate | Rattus norvegicus | |
2.7.11.4 | 2-oxoisopentanoate | less effective than 2-oxoisohexanoate and 2-oxo-3-methylpentanoate | Oryctolagus cuniculus | |
2.7.11.4 | 2-oxoisopentanoate | less effective than 2-oxoisohexanoate and 2-oxo-3-methylpentanoate | Rattus norvegicus | |
2.7.11.4 | Dichloroacetate | weak | Oryctolagus cuniculus | |
2.7.11.4 | Dichloroacetate | weak | Rattus norvegicus | |
2.7.11.4 | additional information | no inhibition by 2-chloropropionate | Oryctolagus cuniculus | |
2.7.11.4 | additional information | no inhibition by 2-chloropropionate | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Rattus norvegicus | branched-chain amino acid metabolism | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Oryctolagus cuniculus | branched-chain amino acid metabolism | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Rattus norvegicus | phosphorylation inactivates EC 1.2.4.4 | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | Oryctolagus cuniculus | phosphorylation inactivates EC 1.2.4.4 | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.4.4 | Rattus norvegicus | - |
- |
- |
2.7.11.4 | Oryctolagus cuniculus | - |
- |
- |
2.7.11.4 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.4.4 | hepatocyte | - |
Rattus norvegicus | - |
2.7.11.4 | hepatocyte | - |
Rattus norvegicus | - |
2.7.11.4 | liver | - |
Rattus norvegicus | - |
2.7.11.4 | liver | - |
Oryctolagus cuniculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | 2 Ser-residues in E1-alpha-subunit | Rattus norvegicus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | 2 Ser-residues in E1-alpha-subunit | Oryctolagus cuniculus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | branched-chain amino acid metabolism | Rattus norvegicus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | branched-chain amino acid metabolism | Oryctolagus cuniculus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | phosphorylation inactivates EC 1.2.4.4 | Rattus norvegicus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | phosphorylation inactivates EC 1.2.4.4 | Oryctolagus cuniculus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | CoA | - |
Rattus norvegicus | |
1.2.4.4 | NAD+ | - |
Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.11.4 | 0.5 | - |
2-Chloroisohexanoate | 37°C | Rattus norvegicus |