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Literature summary extracted from

  • Lau, K.S.; Cooper, A.J.L.; Chuang, D.T.
    Inhibition of the bovine branched-chain 2-oxo acid dehydrogenase complex and its kinase by arylidenepyruvates (1990), Biochim. Biophys. Acta, 1038, 360-366.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.4.4 thiamine diphosphate
-
Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.4.4 4-(2-Thienyl)-2-oxo-3-butenoate
-
Bos taurus
1.2.4.4 4-(3-Thienyl)-2-oxo-3-butenoate non-competitive Bos taurus
1.2.4.4 cinnamylpyruvate non-competitive Bos taurus
1.2.4.4 Furfurylidenepyruvate competitive Bos taurus
2.7.11.4 4-(2-Thienyl)-2-oxo-3-butenoate 2 mM Bos taurus
2.7.11.4 4-(3-Thienyl)-2-oxo-3-butenoate 2 mM Bos taurus
2.7.11.4 Furfurylidenepyruvate 1.85 mM Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.4.4 0.00067
-
3-methyl-2-oxobutanoate
-
Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.4 mitochondrion
-
Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Bos taurus regulatory enzyme of branched-chain 2-oxoacid dehydrogenase complex ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Bos taurus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.4 Bos taurus
-
-
-
2.7.11.4 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.4 liver
-
Bos taurus
-
2.7.11.4 liver
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.4.4 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
Bos taurus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]
-
Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] regulatory enzyme of branched-chain 2-oxoacid dehydrogenase complex Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.4 37
-
assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.4.4 CoA
-
Bos taurus
1.2.4.4 NAD+
-
Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.4.4 0.0005
-
Furfurylidenepyruvate
-
Bos taurus
1.2.4.4 0.15
-
4-(3-Thienyl)-2-oxo-3-butenoate
-
Bos taurus
1.2.4.4 0.5
-
cinnamylpyruvate
-
Bos taurus
2.7.11.4 4.5
-
Furfurylidenepyruvate
-
Bos taurus