EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.105 | acetaldehyde | 2-oxoglutarate dehydrogenase complex | Saccharomyces cerevisiae | |
1.2.1.105 | glyoxylate | 2-oxoglutarate dehydrogenase complex | Saccharomyces cerevisiae |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.2.1.5 | mitochondrion | part of alpha-ketoglutarate dehydrogenase complex | Saccharomyces cerevisiae | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.105 | Saccharomyces cerevisiae | - |
- |
- |
2.2.1.5 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH | Saccharomyces cerevisiae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.105 | 2-oxoglutarate + lipoamide | - |
Saccharomyces cerevisiae | S-succinyldihydrolipoamide + CO2 | - |
? | |
2.2.1.5 | 2-oxoglutarate + acetaldehyde | - |
Saccharomyces cerevisiae | 5-hydroxy-4-oxohexanoate + CO2 | - |
? | |
2.2.1.5 | 2-oxoglutarate + glyoxylate | - |
Saccharomyces cerevisiae | 2-hydroxy-3-oxohexandioate + CO2 | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.2.1.5 | 30 | - |
enzyme assay at | Saccharomyces cerevisiae |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.2.1.5 | 7 | - |
enzyme assay at | Saccharomyces cerevisiae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.2.1.5 | thiamine diphosphate | - |
Saccharomyces cerevisiae |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.105 | 3.3 | - |
glyoxylate | 2-oxoglutarate dehydrogenase complex | Saccharomyces cerevisiae | |
1.2.1.105 | 7.2 | - |
acetaldehyde | 2-oxoglutarate dehydrogenase complex | Saccharomyces cerevisiae |