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Literature summary extracted from

  • Kornfeld, S.; Benziman, M.; Milner, Y.
    alpha-Ketoglutarate dehydrogenase complex of Acetobacter xylinum. Purification and regulatory properties (1977), J. Biol. Chem., 252, 2940-2947.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.105 AMP stimulates 2-oxoglutarate dehydrogenase complex Komagataeibacter xylinus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.105 NADH
-
Komagataeibacter xylinus
1.2.1.105 succinyl-CoA
-
Komagataeibacter xylinus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.105 Mg2+ required, 2-oxoglutarate dehydrogenase complex Komagataeibacter xylinus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.105 Komagataeibacter xylinus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.105 2-oxoglutarate dehydrogenase complex Komagataeibacter xylinus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH Komagataeibacter xylinus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.105 additional information
-
specific activity of the 2-oxoglutarate dehydrogenase complex Komagataeibacter xylinus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.105 2-oxoglutarate + lipoamide
-
Komagataeibacter xylinus S-succinyldihydrolipoamide + CO2
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2.1.105 additional information
-
additional information
-
Komagataeibacter xylinus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.105 7.3 7.6 2-oxoglutarate dehydrogenase complex Komagataeibacter xylinus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.105 6.6 8.4 about 50% of maximal activity at pH 6.6 and at pH 8.4, 2-oxoglutarate dehydrogenase complex Komagataeibacter xylinus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.105 thiamine diphosphate required , 2-oxoglutarate dehydrogenase complex Komagataeibacter xylinus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.105 0.003
-
succinyl-CoA
-
Komagataeibacter xylinus
1.2.1.105 0.02
-
NADH competitive inhibition with respect to NAD+, 2-oxoglutarate dehydrogenase complex Komagataeibacter xylinus