EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.105 | Benzene-1,3-dicarboxylate | - |
Sus scrofa | |
1.2.1.105 | Benzene-1,4-dicarboxylate | - |
Sus scrofa | |
1.2.1.105 | Pyridine-2,4-dicarboxylate | - |
Sus scrofa | |
1.2.1.105 | Pyridine-2,5-dicarboxylate | - |
Sus scrofa | |
1.14.11.4 | Pyridine 2,4-dicarboxylate | - |
Gallus gallus | |
1.14.11.4 | Pyridine 2,5-dicarboxylate | - |
Gallus gallus | |
1.14.11.4 | pyridine 2-carboxylate | - |
Gallus gallus | |
1.14.11.7 | 2-oxoadipate | - |
Gallus gallus | |
1.14.11.7 | 2-oxobutyrate | - |
Gallus gallus | |
1.14.11.7 | 2-oxpentanoate | - |
Gallus gallus | |
1.14.11.7 | 3-oxoglutarate | - |
Gallus gallus | |
1.14.11.7 | adipate | - |
Gallus gallus | |
1.14.11.7 | benzene-1,2-dicarboxylate | - |
Gallus gallus | |
1.14.11.7 | Benzene-1,3-dicarboxylate | - |
Gallus gallus | |
1.14.11.7 | Benzene-1,4-dicarboxylate | - |
Gallus gallus | |
1.14.11.7 | benzoate | - |
Gallus gallus | |
1.14.11.7 | Glutarate | - |
Gallus gallus | |
1.14.11.7 | laevulinate | - |
Gallus gallus | |
1.14.11.7 | malonate | - |
Gallus gallus | |
1.14.11.7 | oxaloacetate | - |
Gallus gallus | |
1.14.11.7 | pyridine-2,3-dicarboxylate | - |
Gallus gallus | |
1.14.11.7 | Pyridine-2,4-dicarboxylate | - |
Gallus gallus | |
1.14.11.7 | Pyridine-2,5-dicarboxylate | - |
Gallus gallus | |
1.14.11.7 | pyridine-2-carboxylate | - |
Gallus gallus | |
1.14.11.7 | pyridine-3,4-dicarboxylate | - |
Gallus gallus | |
1.14.11.7 | pyridine-3,5-dicarboxylate | - |
Gallus gallus | |
1.14.11.7 | pyridine-3-carboxylate | - |
Gallus gallus | |
1.14.11.7 | pyridine-4-carboxylate | - |
Gallus gallus | |
1.14.11.7 | pyruvate | - |
Gallus gallus | |
1.14.11.7 | succinate | - |
Gallus gallus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.105 | Sus scrofa | - |
- |
- |
1.14.11.4 | Gallus gallus | - |
- |
- |
1.14.11.7 | Gallus gallus | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH | Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.1.105 | heart | - |
Sus scrofa | - |
1.14.11.4 | embryo | - |
Gallus gallus | - |
1.14.11.7 | embryo | - |
Gallus gallus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.105 | 2-oxoglutarate + lipoamide | - |
Sus scrofa | S-succinyldihydrolipoamide + CO2 | - |
? | |
1.2.1.105 | additional information | enzyme complex is also active with 2-oxoadipate | Sus scrofa | ? | - |
? | |
1.14.11.7 | procollagen L-proline + 2-oxoglutarate + O2 | proline-labelled polypeptide substrate | Gallus gallus | procollagen trans-3-hydroxy-L-proline + succinate + CO2 | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.105 | 0.4 | - |
Pyridine-2,4-dicarboxylate | - |
Sus scrofa | |
1.2.1.105 | 0.5 | - |
Benzene-1,3-dicarboxylate | - |
Sus scrofa | |
1.2.1.105 | 1.1 | - |
Benzene-1,4-dicarboxylate | - |
Sus scrofa | |
1.2.1.105 | 3 | - |
Pyridine-2,5-dicarboxylate | - |
Sus scrofa | |
1.14.11.7 | 0.003 | - |
Pyridine-2,4-dicarboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 0.015 | - |
Pyridine-2,5-dicarboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 0.2 | - |
pyridine-2-carboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 0.3 | - |
pyridine-3-carboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 0.5 | - |
oxaloacetate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 0.5 | - |
pyridine-3-carboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 0.5 | - |
Benzene-1,3-dicarboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 0.5 | - |
Benzene-1,4-dicarboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 0.5 | - |
pyridine-3,5-dicarboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 0.7 | - |
pyridine-2,3-dicarboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 0.8 | - |
succinate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 1 | - |
2-oxoadipate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 1.3 | - |
benzene-1,2-dicarboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 2 | - |
pyridine-3,4-dicarboxylate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 2.8 | - |
3-oxoglutarate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 3.1 | - |
benzoate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 3.6 | - |
Glutarate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 4.2 | - |
pyruvate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 6 | - |
adipate | - |
Gallus gallus | |
1.14.11.7 | 7.4 | - |
malonate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 8 | - |
laevulinate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 9.9 | - |
2-oxobutyrate | competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus | |
1.14.11.7 | 15 | - |
2-oxopentanoate | above, competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate | Gallus gallus |