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Literature summary extracted from

  • Majamaa, K.; Turpeenniemi-Hujanen, T.M.; Latipää, P.; Gunzler, V.; Hanauske-Abel, H.M.; Hassinen, I.E.; Kivirikko, K.I.
    Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate (1985), Biochem. J., 229, 127-133.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.105 Benzene-1,3-dicarboxylate
-
Sus scrofa
1.2.1.105 Benzene-1,4-dicarboxylate
-
Sus scrofa
1.2.1.105 Pyridine-2,4-dicarboxylate
-
Sus scrofa
1.2.1.105 Pyridine-2,5-dicarboxylate
-
Sus scrofa
1.14.11.4 Pyridine 2,4-dicarboxylate
-
Gallus gallus
1.14.11.4 Pyridine 2,5-dicarboxylate
-
Gallus gallus
1.14.11.4 pyridine 2-carboxylate
-
Gallus gallus
1.14.11.7 2-oxoadipate
-
Gallus gallus
1.14.11.7 2-oxobutyrate
-
Gallus gallus
1.14.11.7 2-oxpentanoate
-
Gallus gallus
1.14.11.7 3-oxoglutarate
-
Gallus gallus
1.14.11.7 adipate
-
Gallus gallus
1.14.11.7 benzene-1,2-dicarboxylate
-
Gallus gallus
1.14.11.7 Benzene-1,3-dicarboxylate
-
Gallus gallus
1.14.11.7 Benzene-1,4-dicarboxylate
-
Gallus gallus
1.14.11.7 benzoate
-
Gallus gallus
1.14.11.7 Glutarate
-
Gallus gallus
1.14.11.7 laevulinate
-
Gallus gallus
1.14.11.7 malonate
-
Gallus gallus
1.14.11.7 oxaloacetate
-
Gallus gallus
1.14.11.7 pyridine-2,3-dicarboxylate
-
Gallus gallus
1.14.11.7 Pyridine-2,4-dicarboxylate
-
Gallus gallus
1.14.11.7 Pyridine-2,5-dicarboxylate
-
Gallus gallus
1.14.11.7 pyridine-2-carboxylate
-
Gallus gallus
1.14.11.7 pyridine-3,4-dicarboxylate
-
Gallus gallus
1.14.11.7 pyridine-3,5-dicarboxylate
-
Gallus gallus
1.14.11.7 pyridine-3-carboxylate
-
Gallus gallus
1.14.11.7 pyridine-4-carboxylate
-
Gallus gallus
1.14.11.7 pyruvate
-
Gallus gallus
1.14.11.7 succinate
-
Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.105 Sus scrofa
-
-
-
1.14.11.4 Gallus gallus
-
-
-
1.14.11.7 Gallus gallus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.105 heart
-
Sus scrofa
-
1.14.11.4 embryo
-
Gallus gallus
-
1.14.11.7 embryo
-
Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.105 2-oxoglutarate + lipoamide
-
Sus scrofa S-succinyldihydrolipoamide + CO2
-
?
1.2.1.105 additional information enzyme complex is also active with 2-oxoadipate Sus scrofa ?
-
?
1.14.11.7 procollagen L-proline + 2-oxoglutarate + O2 proline-labelled polypeptide substrate Gallus gallus procollagen trans-3-hydroxy-L-proline + succinate + CO2
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.105 0.4
-
Pyridine-2,4-dicarboxylate
-
Sus scrofa
1.2.1.105 0.5
-
Benzene-1,3-dicarboxylate
-
Sus scrofa
1.2.1.105 1.1
-
Benzene-1,4-dicarboxylate
-
Sus scrofa
1.2.1.105 3
-
Pyridine-2,5-dicarboxylate
-
Sus scrofa
1.14.11.7 0.003
-
Pyridine-2,4-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 0.015
-
Pyridine-2,5-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 0.2
-
pyridine-2-carboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 0.3
-
pyridine-3-carboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 0.5
-
oxaloacetate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 0.5
-
pyridine-3-carboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 0.5
-
Benzene-1,3-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 0.5
-
Benzene-1,4-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 0.5
-
pyridine-3,5-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 0.7
-
pyridine-2,3-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 0.8
-
succinate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 1
-
2-oxoadipate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 1.3
-
benzene-1,2-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 2
-
pyridine-3,4-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 2.8
-
3-oxoglutarate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 3.1
-
benzoate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 3.6
-
Glutarate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 4.2
-
pyruvate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 6
-
adipate
-
Gallus gallus
1.14.11.7 7.4
-
malonate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 8
-
laevulinate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 9.9
-
2-oxobutyrate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.14.11.7 15
-
2-oxopentanoate above, competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus