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Literature summary extracted from

  • Harding, R.W.; Caroline, D.F.; Wagner, R.P.
    The pyruvate dehydrogenase complex from the mitochondrial fraction of Neurospora crassa (1970), Arch. Biochem. Biophys., 138, 653-661.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.104 citrate 0.25 mM, 29% inhibition, 50.0 mM, 87% inhibition Neurospora crassa
1.2.1.104 MgATP2-
-
 Neurospora crassa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.104 0.017
-
 pyruvate similar values Neurospora crassa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.104 Mg2+ no requirement Neurospora crassa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.104 pyruvate + lipoamide Neurospora crassa in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate S-acetyldihydrolipoamide + CO2
-
 ?
1.2.1.104 pyruvate + lipoamide Neurospora crassa additional reactions of complex, e. g. reduction of K3Fe(CN)6 S-acetyldihydrolipoamide + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Neurospora crassa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.104 pyruvate + lipoamide in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate Neurospora crassa S-acetyldihydrolipoamide + CO2
-
 ?
1.2.1.104 pyruvate + lipoamide additional reactions of complex, e. g. reduction of K3Fe(CN)6 Neurospora crassa S-acetyldihydrolipoamide + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.104 additional information
-
 value for pyruvate dehydrogenase complex: 8.0-9.0 Neurospora crassa

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.104 thiamine diphosphate
-
 Neurospora crassa