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Literature summary extracted from

  • Hirabayashi, T.; Harada, T.
    Isolation and properties of a pyruvate dehydrogenase complex from the yeast Hansenula miso (1972), J. Biochem., 71, 797-804.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.104 pyruvate + lipoamide Hansenula miso in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate S-acetyldihydrolipoamide + CO2
-
 ?
1.2.1.104 pyruvate + lipoamide Hansenula miso low reactivity with 2-ketovalerate S-acetyldihydrolipoamide + CO2
-
 ?
1.2.1.104 pyruvate + lipoamide Hansenula miso additional reactions of complex, e. g. reduction of K3Fe(CN)6 S-acetyldihydrolipoamide + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Hansenula miso
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.104 pyruvate dehydrogenase complex, composed of EC 1.2.4.1, EC 2.3.1.12, EC 1.8.1.4 Hansenula miso

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.104 pyruvate + lipoamide in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate Hansenula miso S-acetyldihydrolipoamide + CO2
-
 ?
1.2.1.104 pyruvate + lipoamide low reactivity with 2-ketovalerate Hansenula miso S-acetyldihydrolipoamide + CO2
-
 ?
1.2.1.104 pyruvate + lipoamide additional reactions of complex, e. g. reduction of K3Fe(CN)6 Hansenula miso S-acetyldihydrolipoamide + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.104 additional information
-
-
 Hansenula miso

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.104 thiamine diphosphate
-
 Hansenula miso