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Literature summary extracted from

  • Harding, R.W.; Caroline, D.F.; Wagner, R.P.
    Pyruvate dehydrogenase complex from Neurospora (1982), Methods Enzymol., 89, 386-391.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.104 MgATP2- 5 mM, 93% inhibition due to phosphorylation Neurospora crassa
1.2.1.104 phosphorylation
-
 Neurospora crassa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.12 dihydrolipoamide + acetyl-CoA Neurospora crassa
-
 S-acetyldihydrolipoamide + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Neurospora crassa
-
-
-
2.3.1.12 Neurospora crassa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.2.1.104 side-chain modification inactivated by phosphorylation Neurospora crassa

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.104
-
 Neurospora crassa
2.3.1.12 pyruvate dehydrogenase complex, composed of EC 1.2.4.1, EC 1.8.1.4, EC 2.3.1.12 Neurospora crassa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.12 mycelium
-
 Neurospora crassa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.12 dihydrolipoamide + acetyl-CoA
-
 Neurospora crassa S-acetyldihydrolipoamide + CoA
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.104 additional information
-
 value for pyruvate dehydrogenase complex: 8.0-9.0 Neurospora crassa
1.2.1.104 8 9
-
 Neurospora crassa

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.104 thiamine diphosphate
-
 Neurospora crassa