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Literature summary extracted from

  • Evces, S.; Lindahl, R.
    Characterization of rat cornea aldehyde dehydrogenase (1989), Arch. Biochem. Biophys., 274, 518-524.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.5 Disulfiram 0.025 mM, 99% inhibition of activity with NADP+, 80% inhibition of activity with activity with NAD+ Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.5 0.003
-
 NAD+
-
 Rattus norvegicus
1.2.1.5 0.2
-
 benzaldehyde enzyme from cornea, reaction with NADP+ Rattus norvegicus
1.2.1.5 0.3
-
 benzaldehyde enzyme from HTC hepatoma cells, reaction with NADP+ Rattus norvegicus
1.2.1.5 0.42
-
 NADP+
-
 Rattus norvegicus
1.2.1.5 2.7
-
 propanal enzyme from HTC hepatoma cells, reaction with NAD+ Rattus norvegicus
1.2.1.5 3
-
 NAD+ enzyme from cornea, reaction with propanal Rattus norvegicus
1.2.1.5 5.7
-
 propanal enzyme from cornea, reaction with NAD+ Rattus norvegicus
1.2.1.5 35
-
 NAD+ enzyme from HTC hepatoma cells, reaction with propanal Rattus norvegicus
1.2.1.5 240
-
 NADP+ enzyme from HTC hepatoma cells, reaction with benzaldehyde Rattus norvegicus
1.2.1.5 260
-
 NADP+ enzyme from cornea, reaction with benzaldehyde Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.5 51000
-
 2 * 51000, SDS-PAGE Rattus norvegicus
1.2.1.5 100000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.5 additional information Rattus norvegicus the enzyme plays a role in oxidation of a variety of aldehydes generated by lipid metabolism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.5 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.5
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.5 cornea
-
 Rattus norvegicus
-
1.2.1.5 HTC cell
-
 Rattus norvegicus
-
1.2.1.5 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.5 110.5
-
 liver enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.5 2,5-dihydroxybenzaldehyde + NADP+ + H2O
-
 Rattus norvegicus 2,5-dihydroxybenzoate + NADPH + H+
-
 ?
1.2.1.5 2-methylbutyraldehyde + NAD+ + H2O
-
 Rattus norvegicus 2-methylbutyrate + NADH + H+
-
 ?
1.2.1.5 3-hydroxybenzaldehyde + NADP+ + H2O
-
 Rattus norvegicus 3-hydroxybenzoate + NADPH + H+
-
 ?
1.2.1.5 4-carboxybenzaldehyde + NADP+ + H2O
-
 Rattus norvegicus 4-carboxybenzoate + NADPH + H+
-
 ?
1.2.1.5 4-chlorobenzaldehyde + NADP+ + H2O
-
 Rattus norvegicus 4-chlorobenzoate + NADPH + H+
-
 ?
1.2.1.5 4-nitrobenzaldehyde + NAD+ + H2O
-
 Rattus norvegicus 4-nitrobenzoate + NADH + H+
-
 ?
1.2.1.5 acetaldehyde + NADP+ + H2O
-
 Rattus norvegicus acetate + NADPH + H+
-
 ?
1.2.1.5 benzaldehyde + NADP+
-
 Rattus norvegicus benzoate + NADPH
-
 ?
1.2.1.5 dodecanal + NADP+ + H2O
-
 Rattus norvegicus dodecanoate + NADPH + H+
-
 ?
1.2.1.5 hexanal + NAD+ + H2O
-
 Rattus norvegicus hexanoate + NADH + H+
-
 ?
1.2.1.5 isobutanal + NAD+ + H2O
-
 Rattus norvegicus isobutyrate + NADH + H+
-
 ?
1.2.1.5 additional information the enzyme plays a role in oxidation of a variety of aldehydes generated by lipid metabolism Rattus norvegicus ?
-
 ?
1.2.1.5 nonanal + NADP+ + H2O
-
 Rattus norvegicus nonanoate + NADPH + H+
-
 ?
1.2.1.5 octanal + NAD+ + H2O
-
 Rattus norvegicus octanoate + NADH + H+
-
 ?
1.2.1.5 phenylacetaldehyde + NADP+ + H2O
-
 Rattus norvegicus phenylacetate + NADPH + H+
-
 ?
1.2.1.5 propanal + NAD+ + H2O
-
 Rattus norvegicus propionate + NADH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.5 dimer 2 * 51000, SDS-PAGE Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.2.1.5 55
-
 4 min, 98% loss of activity Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2.1.5 additional information
-
 additional information
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.5 8.5
-
 activity with NADP+ Rattus norvegicus
1.2.1.5 10
-
 activity with NAD+, broad plateau from pH 5 to 8 followed by a sharp increase in activity to pH 10 Rattus norvegicus