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Literature summary extracted from

  • Pietruszko, R.; Yonetani, T.
    Aldehyde dehydrogenases from liver (1981), Methods Enzymol., 71, 772-781.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.0002
-
 acetaldehyde isoenzyme F2 Equus caballus
1.2.1.3 0.003
-
 acetaldehyde isoenzyme E2 Homo sapiens
1.2.1.3 0.003
-
 NAD+ isoenzyme F1 Equus caballus
1.2.1.3 0.0125
-
 NAD+ cytoplasmic isoenzyme Ovis aries
1.2.1.3 0.03
-
 NAD+ isoenzyme F2 Equus caballus
1.2.1.3 0.03
-
 acetaldehyde isoenzyme E1 Homo sapiens
1.2.1.3 0.04
-
 NAD+ isoenzyme E1 Homo sapiens
1.2.1.3 0.07
-
 NAD+ isoenzyme E2 Homo sapiens
1.2.1.3 0.07
-
 acetaldehyde isoenzyme F1 Equus caballus
1.2.1.3 0.077
-
 NAD+ mitochondrial isoenzyme Ovis aries

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 cytoplasm
-
 Homo sapiens 5737
-
1.2.1.3 cytoplasm
-
 Ovis aries 5737
-
1.2.1.3 mitochondrion
-
 Homo sapiens 5739
-
1.2.1.3 mitochondrion
-
 Ovis aries 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.3 52000
-
 x * 52000, isoenzyme F1 Equus caballus
1.2.1.3 53000
-
 4 * 53000, SDS-PAGE Ovis aries
1.2.1.3 53000
-
 x * 53000, isoenzyme F2 Equus caballus
1.2.1.3 54000
-
 x * 54000, isoenzyme E1 and E2 Homo sapiens
1.2.1.3 205000
-
 mitochondrial enzyme, gel filtration Ovis aries
1.2.1.3 212000
-
 cytoplasmic enzyme, gel filtration Ovis aries
1.2.1.3 225000
-
-
 Homo sapiens
1.2.1.3 230000
-
-
 Equus caballus
1.2.1.3 230000
-
 isoenzyme E2 Homo sapiens
1.2.1.3 240000
-
 isoenzyme F2 Equus caballus
1.2.1.3 245000
-
 isoenzyme E1 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Equus caballus
-
-
-
1.2.1.3 Homo sapiens
-
-
-
1.2.1.3 Ovis aries
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.3
-
 Homo sapiens
1.2.1.3
-
 Equus caballus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 liver
-
 Homo sapiens
-
1.2.1.3 liver
-
 Ovis aries
-
1.2.1.3 liver
-
 Equus caballus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.3 0.37
-
 isoenzyme F1 Equus caballus
1.2.1.3 0.54
-
 isoenzyme E1 Homo sapiens
1.2.1.3 0.8
-
 isoenzyme F2 Equus caballus
1.2.1.3 1.3
-
 isoenzyme E2 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 acetaldehyde + NAD+ + H2O
-
 Homo sapiens acetate + NADH + H+
-
 ir
1.2.1.3 acetaldehyde + NAD+ + H2O
-
 Ovis aries acetate + NADH + H+
-
 ir
1.2.1.3 acetaldehyde + NAD+ + H2O
-
 Equus caballus acetate + NADH + H+
-
 ir

Subunits

EC Number Subunits Comment Organism
1.2.1.3 ? x * 53000, isoenzyme F2 Equus caballus
1.2.1.3 ? x * 52000, isoenzyme F1 Equus caballus
1.2.1.3 ? x * 54000, isoenzyme E1 and E2 Homo sapiens
1.2.1.3 tetramer
-
 Homo sapiens
1.2.1.3 tetramer 4 * 53000, SDS-PAGE Ovis aries

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.3 8.6
-
 isoenzyme E1 Homo sapiens
1.2.1.3 9.5
-
 isoenzyme E2 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens
1.2.1.3 NAD+
-
 Ovis aries
1.2.1.3 NAD+
-
 Equus caballus