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Literature summary extracted from

  • Kurys, G.; Ambroziak, W.; Pietruszko, R.
    Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde (1989), J. Biol. Chem., 264, 4715-4721.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.014 0.015 NAD+ reaction with 4-aminobutyraldehyde Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
 usual livers contains cytosolic ALDH1 and ALDH2, the atypical phenotype contains only the ALDH1 isoenzyme and immunologically cross-reactive material resulting from a mutation of the ALDH2 locus. 50% of orientals are atypical in respect to ALDH isoenzymes
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.3 isoenzyme ALDH1 and ALDH2 from normal livers, ALDH1 from the atypical phenotype Homo sapiens
1.2.1.3 isoenzyme E3 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 4-aminobutyraldehyde + NAD+ + H2O
-
 Homo sapiens 4-aminobutyrate + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.3 7.4
-
 reaction with gamma-aminobutyrate Homo sapiens
1.2.1.3 9.5
-
 reaction with propanal Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens