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Literature summary extracted from

  • Izaguirre, G.; Kikonyogo, A.; Pietruszko, R.
    Methylglyoxal as substrate and inhibitor of human aldehyde dehydrogenase: comparison of kinetic properties among the three isoenzymes (1998), Comp. Biochem. Physiol. B, 119, 747-754.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 methylglyoxal substrate inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.001
-
3,4-dihydroxyphenyl acetaldehyde pH 7.1, isoenzyme 2 Homo sapiens
1.2.1.3 0.002
-
acetaldehyde pH 9.0, isoenzyme E2 Homo sapiens
1.2.1.3 0.003
-
acetaldehyde pH 7.4, isoenzyme E2 Homo sapiens
1.2.1.3 0.008
-
4-aminobutyrate minor component of enzyme E3, pH 7.4 Homo sapiens
1.2.1.3 0.0086
-
methylglyoxal pH 7.4, isoenzyme E2 Homo sapiens
1.2.1.3 0.014
-
4-aminobutyrate major component of enzyme E3, pH 7.4 Homo sapiens
1.2.1.3 0.021
-
methylglyoxal pH 9.0, isoenzyme E2 Homo sapiens
1.2.1.3 0.046
-
glycoaldehyde isoenzyme 2, pH 7.4 Homo sapiens
1.2.1.3 0.09
-
Betaine aldehyde minor component of enzyme E3, pH 7.4 Homo sapiens
1.2.1.3 0.26
-
Betaine aldehyde major component of enzyme form E3, pH 7.4 Homo sapiens
1.2.1.3 0.552
-
methylglyoxal minor component of enzyme form E3, pH 7.4 Homo sapiens
1.2.1.3 0.586
-
methylglyoxal major component of enzyme form E3, pH 7.4 Homo sapiens
1.2.1.3 0.958
-
methylglyoxal minor component of enzyme form E3, pH 9.0 Homo sapiens
1.2.1.3 1.876
-
methylglyoxal major component of enzyme form E3, pH 9.0 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
isoenzyme E1, E2, and E3
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 4-aminobutyraldehyde + NAD+ + H2O
-
Homo sapiens 4-aminobutyrate + NADH
-
?
1.2.1.3 acetaldehyde + NAD+ + H2O
-
Homo sapiens acetate + NADH + H+
-
?
1.2.1.3 betaine aldehyde + NAD+ + H2O
-
Homo sapiens betaine + NADH
-
?
1.2.1.3 glycolaldehyde + NAD+ + H2O
-
Homo sapiens glycolate + NADH
-
?
1.2.1.3 methylglyoxal + NAD+ + H2O
-
Homo sapiens methylglyoxalate + NADH
-
?
1.2.1.3 propanal + NAD+ + H2O
-
Homo sapiens propionate + NADH
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.3 2
-
methylglyoxal major component of enzyme E3, pH 9.0 Homo sapiens
1.2.1.3 12
-
methylglyoxal minor component of enzyme E3, pH 9.0 Homo sapiens