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Literature summary extracted from

  • Lindahl, R.; Evces, S.
    Rat liver aldehyde dehydrogenase. II. Isolation and characterization of four inducible isozymes (1984), J. Biol. Chem., 259, 11991-11996.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.3 diethylstilbestrol activates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 Disulfiram
-
 Rattus norvegicus
1.2.1.3 p-hydroxymercuribenzoate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.0023
-
 NAD+ enzyme from promotion phase of hepatocarcinogenesis Rattus norvegicus
1.2.1.3 0.0077
-
 NAD+ phenobarbital-inducible enzyme Rattus norvegicus
1.2.1.3 1.3
-
 propanal enzyme from promotion phase of hepatocarcinogenesis Rattus norvegicus
1.2.1.3 1.3
-
 benzaldehyde phenobarbital-inducible enzyme Rattus norvegicus
1.2.1.3 1.4
-
 propanal phenobarbital-inducible enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Rattus norvegicus
-
 enzyme from the promotion phase of hepatocarcinogenesis and phenobabital-inducible enzyme
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.3 enzyme from promotion phase of hepatocarcinogenesis and phenobarbital-inducible enzyme Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.3 2.07
-
 enzyme from the promotion phase of hepatocarcinogenesis Rattus norvegicus
1.2.1.3 3.86
-
 phenobarbital-inducible enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 benzaldehyde + NAD+ + H2O promotion-associated enzyme, no activity with phenobarbital-inducible enzyme Rattus norvegicus benzoate + NADH + H+
-
 ?
1.2.1.3 phenylacetaldehyde + NAD+ + H2O
-
 Rattus norvegicus phenylacetate + NADH + H+
-
 ?
1.2.1.3 propanal + NAD+ + H2O
-
 Rattus norvegicus propionate + NADH
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.2.1.3 50
-
 15 min, retains 70% of the original activity Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.3 10
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.3 9 10 pH 9: about 35% of maximal activity, pH 10: optimum Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 additional information NADP+: promotion-associated enzyme shows 1% of the activity with NAD+, phenobarbital-associated enzyme shows no activity Rattus norvegicus
1.2.1.3 NAD+
-
 Rattus norvegicus