Literature summary extracted from

Giordani A.; Pevarello P.; Cini, M.; Bormetti, R.; Greco, F.; Toma, S.; Speciale, C.; Varasi, M.
4-phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase (1998), Bioorg. Med. Chem. Lett., 8, 2907-2012.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.13.9	2-benzyl-4-(3,4-dichlorophenyl)-4-oxo-butanoic acid	-	Rattus norvegicus
1.14.13.9	2-hydroxy-4-(3,4-dichlorophenyl)-4-oxobutanoic acid	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.13.9	L-kynurenine + NADPH + O2	Rattus norvegicus	key enzyme in the kynurenine pathway of tryptophan degradation	? + NADP+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.13.9	Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.13.9	L-kynurenine + NADPH + O2	key enzyme in the kynurenine pathway of tryptophan degradation	Rattus norvegicus	? + NADP+	-	?

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Release 2023.1 (January 2023)