EC Number | General Stability | Organism |
---|---|---|
1.1.1.236 | activity rapidly lost during purification | Datura stramonium |
1.1.1.236 | activity rapidly lost during purification | Atropa belladonna |
1.1.1.236 | activity rapidly lost during purification | Hyoscyamus niger |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.236 | p-chloromercuribenzoic acid | - |
Hyoscyamus niger |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.236 | 0.0061 | - |
NADPH | - |
Hyoscyamus niger | |
1.1.1.236 | 0.0076 | - |
NADH | - |
Hyoscyamus niger | |
1.1.1.236 | 0.017 | - |
NADPH | - |
Datura stramonium | |
1.1.1.236 | 0.0211 | - |
NADPH | - |
Hyoscyamus niger | |
1.1.1.236 | 0.023 | - |
NADPH | - |
Datura stramonium | |
1.1.1.236 | 0.034 | - |
tropinone | - |
Hyoscyamus niger | |
1.1.1.236 | 0.0351 | - |
tropinone | - |
Hyoscyamus niger | |
1.1.1.236 | 0.22 | - |
tropinone | - |
Datura stramonium | |
1.1.1.236 | 0.251 | - |
NADP+ | - |
Hyoscyamus niger | |
1.1.1.236 | 0.265 | - |
N-propylyl-4-piperidone | - |
Hyoscyamus niger | |
1.1.1.236 | 0.534 | - |
4-ethylcyclohexanone | - |
Hyoscyamus niger | |
1.1.1.236 | 0.77 | - |
N-Methyl-4-piperidone | - |
Hyoscyamus niger | |
1.1.1.236 | 0.83 | - |
tropinone | - |
Datura stramonium | |
1.1.1.236 | 2.03 | - |
4-methylcyclohexanone | - |
Hyoscyamus niger | |
1.1.1.236 | 7.58 | - |
3-methylcyclohexanone | - |
Hyoscyamus niger | |
1.1.1.236 | 21.6 | - |
4-Piperidone | - |
Hyoscyamus niger |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.236 | 25000 | 55000 | TRII preparation is not yet pure and shows numerous bands | Datura stramonium |
1.1.1.236 | 29000 | - |
3 * 29000, SDS-PAGE | Hyoscyamus niger |
1.1.1.236 | 29000 | - |
4 * 29000, SDS-PAGE | Hyoscyamus niger |
1.1.1.236 | 69000 | - |
minor peak, gel filtration | Hyoscyamus niger |
1.1.1.236 | 103000 | - |
major peak, gel filtration | Hyoscyamus niger |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.236 | tropinone + NADPH + H+ | Datura inoxia | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Datura stramonium | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Atropa belladonna | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Hyoscyamus muticus | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Hyoscyamus pusillus | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Hyoscyamus canariensis | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Hyoscyamus bohemicus | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Physochlaina orientalis | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Physalis philadelphica | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Physalis edulis | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Calystegia sepium | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Alkekengi officinarum | - |
pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | Hyoscyamus niger | reverse reaction very inefficient, about 1.3% of the forward activity | pseudotropine + NADP+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.236 | Alkekengi officinarum | - |
- |
- |
1.1.1.236 | Atropa belladonna | - |
- |
- |
1.1.1.236 | Calystegia sepium | - |
- |
- |
1.1.1.236 | Datura inoxia | - |
- |
- |
1.1.1.236 | Datura stramonium | - |
- |
- |
1.1.1.236 | Hyoscyamus bohemicus | - |
- |
- |
1.1.1.236 | Hyoscyamus canariensis | - |
- |
- |
1.1.1.236 | Hyoscyamus muticus | - |
- |
- |
1.1.1.236 | Hyoscyamus niger | - |
- |
- |
1.1.1.236 | Hyoscyamus pusillus | - |
- |
- |
1.1.1.236 | no activity in Brassica campestris | - |
- |
- |
1.1.1.236 | no activity in Browallia americana | - |
- |
- |
1.1.1.236 | no activity in Nicotiana tabacum | - |
tobacco | - |
1.1.1.236 | Physalis edulis | - |
- |
- |
1.1.1.236 | Physalis philadelphica | - |
- |
- |
1.1.1.236 | Physochlaina orientalis | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.236 | - |
Datura stramonium |
1.1.1.236 | - |
Hyoscyamus niger |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.236 | flower | - |
Atropa belladonna | - |
1.1.1.236 | leaf | - |
Atropa belladonna | - |
1.1.1.236 | root | - |
Datura inoxia | - |
1.1.1.236 | root | - |
Atropa belladonna | - |
1.1.1.236 | root | - |
Hyoscyamus niger | - |
1.1.1.236 | root | - |
Physalis philadelphica | - |
1.1.1.236 | root | - |
Physalis edulis | - |
1.1.1.236 | root | - |
Calystegia sepium | - |
1.1.1.236 | root | - |
Alkekengi officinarum | - |
1.1.1.236 | root | hairy roots | Datura stramonium | - |
1.1.1.236 | stem | - |
Datura stramonium | - |
1.1.1.236 | stem | - |
Atropa belladonna | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.236 | 7.79 | - |
- |
Datura stramonium |
EC Number | Storage Stability | Organism |
---|---|---|
1.1.1.236 | -20°C, stable for at least 3 months | Datura stramonium |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.236 | 2-methyl-cyclohexanone + NADPH | - |
Hyoscyamus niger | 2-methylcyclohexanol + NADP+ | - |
? | |
1.1.1.236 | 3-methyl-cyclohexanone + NADPH | - |
Hyoscyamus niger | 3-methylcyclohexanol + NADP+ | - |
? | |
1.1.1.236 | 4-ethyl-cyclohexanone + NADPH | - |
Datura stramonium | 4-ethylcyclohexanol + NADP+ | - |
? | |
1.1.1.236 | 4-ethyl-cyclohexanone + NADPH | - |
Hyoscyamus niger | 4-ethylcyclohexanol + NADP+ | - |
? | |
1.1.1.236 | 4-methyl-cyclohexanone + NADPH | - |
Datura stramonium | 4-methylcyclohexanol + NADP+ | - |
? | |
1.1.1.236 | 4-methyl-cyclohexanone + NADPH | - |
Hyoscyamus niger | 4-methylcyclohexanol + NADP+ | - |
? | |
1.1.1.236 | 4-piperidone + NADPH | - |
Hyoscyamus niger | piperidine-4-ol + NADP+ | - |
? | |
1.1.1.236 | 6-hydroxytropinone + NADPH | - |
Datura stramonium | ? + NADP+ | - |
? | |
1.1.1.236 | 6-hydroxytropinone + NADPH | - |
Hyoscyamus niger | ? + NADP+ | - |
? | |
1.1.1.236 | N-methyl-4-piperidone + NADPH | - |
Datura stramonium | N-methylpiperidin-4-ol + NADP+ | - |
? | |
1.1.1.236 | N-methyl-4-piperidone + NADPH | - |
Hyoscyamus niger | N-methylpiperidin-4-ol + NADP+ | - |
? | |
1.1.1.236 | N-propyl-4-piperidone + NADPH | - |
Datura stramonium | N-propylpiperidin-4-ol + NADP+ | - |
? | |
1.1.1.236 | N-propyl-4-piperidone + NADPH | - |
Hyoscyamus niger | N-propylpiperidin-4-ol + NADP+ | - |
? | |
1.1.1.236 | tetrahydrothiopyran-4-one + NADPH | - |
Datura stramonium | tetrahydrothiopyran-4-ol + NADP+ | - |
? | |
1.1.1.236 | tetrahydrothiopyran-4-one + NADPH | - |
Hyoscyamus niger | tetrahydrothiopyran-4-ol + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Datura inoxia | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Datura stramonium | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Atropa belladonna | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Hyoscyamus niger | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Hyoscyamus muticus | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Hyoscyamus pusillus | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Hyoscyamus canariensis | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Hyoscyamus bohemicus | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Physochlaina orientalis | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Physalis philadelphica | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Physalis edulis | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Calystegia sepium | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | - |
Alkekengi officinarum | pseudotropine + NADP+ | - |
? | |
1.1.1.236 | tropinone + NADPH + H+ | reverse reaction very inefficient, about 1.3% of the forward activity | Hyoscyamus niger | pseudotropine + NADP+ | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.236 | tetramer | 4 * 29000, SDS-PAGE | Hyoscyamus niger |
1.1.1.236 | trimer | - |
Datura stramonium |
1.1.1.236 | trimer | - |
Atropa belladonna |
1.1.1.236 | trimer | 3 * 29000, SDS-PAGE | Hyoscyamus niger |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.236 | 5.3 | 6.5 | - |
Hyoscyamus niger |
1.1.1.236 | 5.8 | - |
forward reaction | Hyoscyamus niger |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.236 | 4 | 5 | reverse oxidative activities | Hyoscyamus niger |
1.1.1.236 | 4.5 | 8.5 | tolerant to pH changes over a wide range | Datura stramonium |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.236 | 5.8 | 8.5 | more acidic buffers inactivate the enzyme highly, 8% of the maximum activity at pH 4.5, more alkaline buffers inhibit the activity less strongly, 61% of the maximum activity at pH 8.5 | Hyoscyamus niger |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.236 | NADPH | - |
Hyoscyamus niger | |
1.1.1.236 | NADPH | activity exclusively with NADPH, not active with NADH | Datura stramonium |