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Literature summary extracted from

  • Jackson, R.C.; Weber, G.
    IMP dehydrogenase, an enzyme linked with proliferation and malignancy (1975), Nature, 256, 331-333.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 NAD+ 50% inhibition at 0.62 mM Rattus norvegicus
1.1.1.205 xanthosine 5'-phosphate
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O Rattus norvegicus enzyme linked to proliferation and malignancy xanthosine 5'-phosphate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Rattus norvegicus
-
 hepatoma
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.205 liver
-
 Rattus norvegicus
-
1.1.1.205 spleen
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.205 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
 Rattus norvegicus xanthosine 5'-phosphate + NADH
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O enzyme linked to proliferation and malignancy Rattus norvegicus xanthosine 5'-phosphate + NADH
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.205 8.1
-
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 additional information
-
 additional information
-
 Rattus norvegicus