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Literature summary extracted from

  • Holmes, E.W.; Pehlke, D.M.; Kelley, W.N.
    Human IMP dehydrogenase. Kinetics and regulatory properties (1974), Biochim. Biophys. Acta, 364, 209-217.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 6-mercaptopurine ribonucleotide
-
 Homo sapiens
1.1.1.205 allopurinol ribonucleotide
-
 Homo sapiens
1.1.1.205 AMP
-
 Homo sapiens
1.1.1.205 GMP
-
 Homo sapiens
1.1.1.205 additional information inhibition by purine and pyrimidine compounds Homo sapiens
1.1.1.205 Mycophenolic acid
-
 Homo sapiens
1.1.1.205 xanthosine 5'-phosphate competitive with respect to IMP Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.205 0.014
-
 IMP
-
 Homo sapiens
1.1.1.205 0.046
-
 NAD+
-
 Homo sapiens
1.1.1.205 17
-
 K+
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.205 cytosol
-
 Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.205 K+ monovalent cation required for maximal activity Homo sapiens
1.1.1.205 NH4+ K+ can be partially replaced by NH4+ Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.205
-
 Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.205 IMP + NAD+ + H2O = XMP + NADH + H+ ordered sequential mechanism Homo sapiens
a
1.1.1.205 IMP + NAD+ + H2O = XMP + NADH + H+ IMP binds first, XMP is released last Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.205 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
 Homo sapiens xanthosine 5'-phosphate + NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 0.03
-
 xanthosine 5'-phosphate
-
 Homo sapiens
1.1.1.205 0.1
-
 GMP
-
 Homo sapiens
1.1.1.205 0.53
-
 AMP
-
 Homo sapiens