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Literature summary extracted from

  • Heyde, E.; Nagabhushanam, A.; Vonarx, M.; Morrison, J.F.
    Studies on inosine monophosphate dehydrogenase. Steady state kinetics (1976), Biochim. Biophys. Acta, 429, 645-660.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 GMP competitive with respect to IMP, non competitive with respect to NAD+ and K+ Klebsiella aerogenes
1.1.1.205 Li+ competitive to K+ Klebsiella aerogenes
1.1.1.205 NADH poor inhibitor, product inhibition, non competitive Klebsiella aerogenes
1.1.1.205 nicotinic acid inhibitory analog of NAD+, non-competitive with respect to IMP and K+ Klebsiella aerogenes
1.1.1.205 xanthosine 5'-phosphate competitive with respect to IMP, non competitive with respect to NAD and K+ Klebsiella aerogenes

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Klebsiella aerogenes
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.205 IMP + NAD+ + H2O = XMP + NADH + H+ IMP and K+ can bind randomly to the free enzyme, while NAD+ does not react unless K+ or both K+ and IMP are present on the enzyme Klebsiella aerogenes
a
1.1.1.205 IMP + NAD+ + H2O = XMP + NADH + H+ mechanism is partially random Klebsiella aerogenes
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
 Klebsiella aerogenes xanthosine 5'-phosphate + NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
 Klebsiella aerogenes

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 additional information
-
 additional information
-
 Klebsiella aerogenes