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Literature summary extracted from
- IMP dehydrogenase and action of antimetabolites in human cultured blast cells (1990), Biochim. Biophys. Acta, 1051, 209-214.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.205 | NADH | - |
Homo sapiens |  |
| 1.1.1.205 | ribavirin 5'-monophosphate | competitive with respect to IMP | Homo sapiens | |
| 1.1.1.205 | thiazole-4-carboxamide adenine dinucleotide | inhibitory mechanism | Homo sapiens | |
| 1.1.1.205 | tiazofurin | - |
Homo sapiens | |
| 1.1.1.205 | xanthosine 5'-phosphate | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.205 | additional information | - |
additional information | - |
Homo sapiens |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.205 | 60000 | - |
SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.205 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.205 | MOLT 4F human T-lymphoblasts | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.205 | B-lymphoblast | - |
Homo sapiens | - |
| 1.1.1.205 | BALL-1 cell | - |
Homo sapiens | - |
| 1.1.1.205 | K-562 cell | - |
Homo sapiens | - |
| 1.1.1.205 | MOLT-4F cell | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.205 | additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.205 | inosine 5'-phosphate + NAD+ + H2O | - |
Homo sapiens | xanthosine 5'-phosphate + NADH | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.205 | NAD+ | - |
Homo sapiens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.205 | 0.000075 | - |
thiazole-4-carboxamide adenine dinucleotide | - |
Homo sapiens | |
| 1.1.1.205 | 0.00058 | - |
ribavirin 5'-monophosphate | - |
Homo sapiens | |
| 1.1.1.205 | 0.085 | - |
xanthosine 5'-phosphate | - |
Homo sapiens | |
| 1.1.1.205 | 0.094 | - |
NADH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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