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Literature summary extracted from

  • Robins, R.K.; Revankar, G.R.; McKernan, P.A.; Murray, B.K.; Kirsi, J.J.; North, J.A.
    The importance of IMP dehydrogenase inhibition in the broad spectrum antiviral activity of ribavirin and selenazofurin (1985), Adv. Enzyme Regul., 24, 29-43.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 Bredinin
-
 Chlorocebus aethiops
1.1.1.205 ribavirin potent competitive inhibition, shows anti-viral activity in vivo, detailed overview Parainfluenza virus
1.1.1.205 ribavirin potent competitive inhibition, shows anti-viral activity in vivo, detailed overview Vaccinia virus
1.1.1.205 ribavirin 5'-monophosphate
-
 Chlorocebus aethiops
1.1.1.205 Selenazofurin inhibition (in vivo) by the NAD analog formed intracellularly Chlorocebus aethiops
1.1.1.205 Selenazofurin potent competitive inhibition, shows anti-viral activity in vivo, detailed overview, a complete reversal of the antiviral activity of selenazofurin was obtained by addition of guanosine and selenazofurin at varying concentrations Parainfluenza virus
1.1.1.205 Selenazofurin potent competitive inhibition, shows anti-viral activity in vivo, detailed overview Vaccinia virus
1.1.1.205 thiazole-4-carboxamide adenine dinucleotide
-
 Chlorocebus aethiops
1.1.1.205 tiazofurin
-
 Chlorocebus aethiops
1.1.1.205 tiazofurin
-
 Parainfluenza virus
1.1.1.205 tiazofurin
-
 Vaccinia virus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O Vaccinia virus rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview xanthosine 5'-phosphate + NADH
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O Parainfluenza virus rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview xanthosine 5'-phosphate + NADH
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O Vaccinia virus Elstree rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview xanthosine 5'-phosphate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Chlorocebus aethiops
-
 vero cell-line infected with vaccina virus and parainfluenza virus type 3 strain C243
-
1.1.1.205 Parainfluenza virus
-
 type 3, strain C243, propagated in Vero cells
-
1.1.1.205 Vaccinia virus
-
 propagated in Vero cells
-
1.1.1.205 Vaccinia virus Elstree
-
 propagated in Vero cells
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
 Vaccinia virus xanthosine 5'-phosphate + NADH
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
 Chlorocebus aethiops xanthosine 5'-phosphate + NADH
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
 Parainfluenza virus xanthosine 5'-phosphate + NADH
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview Vaccinia virus xanthosine 5'-phosphate + NADH
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview Parainfluenza virus xanthosine 5'-phosphate + NADH
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
 Vaccinia virus Elstree xanthosine 5'-phosphate + NADH
-
 ?
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview Vaccinia virus Elstree xanthosine 5'-phosphate + NADH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
 Chlorocebus aethiops
1.1.1.205 NAD+
-
 Parainfluenza virus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 0.00025
-
 ribavirin 5'-monophosphate
-
 Chlorocebus aethiops