EC Number | General Stability | Organism |
---|---|---|
1.1.1.205 | bovine serum albumin stabilizes during dialysis | Rattus norvegicus |
1.1.1.205 | purified enzyme very unstable | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.205 | additional information | inhibition by products and antimetabolites | Rattus norvegicus | |
1.1.1.205 | NAD+ | substrate inhibition at high concentration | Rattus norvegicus | |
1.1.1.205 | NADH | - |
Rattus norvegicus | |
1.1.1.205 | ribavirin 5'-monophosphate | - |
Rattus norvegicus | |
1.1.1.205 | thiazole-4-carboxamide adenine dinucleotide | - |
Rattus norvegicus | |
1.1.1.205 | xanthosine 5'-phosphate | competitive inhibition | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.205 | 0.023 | - |
IMP | - |
Rattus norvegicus | |
1.1.1.205 | 0.065 | - |
NAD+ | - |
Rattus norvegicus | |
1.1.1.205 | 7.8 | - |
K+ | - |
Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.205 | 60000 | - |
4 * 60000, rat hepatoma 3924 A cells, SDS-PAGE | Rattus norvegicus |
1.1.1.205 | 245000 | - |
rat hepatoma 3924 A cells, gel filtration | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.205 | Rattus norvegicus | - |
hepatoma 3924A | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.205 | hepatoma cells 3924 A | Rattus norvegicus |
1.1.1.205 | homogeneitiy | Rattus norvegicus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ | enzyme acts on the hydroxyl group of the hydrated derivative of the substrate, ordered bi-bi mechanism | Rattus norvegicus | |
1.1.1.205 | IMP + NAD+ + H2O = XMP + NADH + H+ | IMP binds first, followed by NAD+, NADH dissociates from the ternary complex first, then XMP is released | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.205 | Morris hepatoma 3924A cell | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.205 | 1.7 | - |
- |
Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
1.1.1.205 | -70°C, 10 mg/ml bovine serum albumin, 3 weeks, 15% loss of activity | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.205 | inosine 5'-phosphate + NAD+ + H2O | - |
Rattus norvegicus | xanthosine 5'-phosphate + NADH | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.205 | tetramer | 4 * 60000, rat hepatoma 3924 A cells, SDS-PAGE | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.205 | NAD+ | - |
Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.205 | 0.0008 | - |
ribavirin 5'-monophosphate | - |
Rattus norvegicus | |
1.1.1.205 | 0.0013 | - |
thiazole-4-carboxamide adenine dinucleotide | - |
Rattus norvegicus | |
1.1.1.205 | 0.136 | - |
xanthosine 5'-phosphate | - |
Rattus norvegicus | |
1.1.1.205 | 0.21 | - |
NADH | - |
Rattus norvegicus |