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Literature summary extracted from

  • Yamada, Y.; Natsumeda, Y.; Weber, G.
    Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase (1988), Biochemistry, 27, 2193-2196.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.1.1.205 bovine serum albumin stabilizes during dialysis Rattus norvegicus
1.1.1.205 purified enzyme very unstable Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 additional information inhibition by products and antimetabolites Rattus norvegicus
1.1.1.205 NAD+ substrate inhibition at high concentration Rattus norvegicus
1.1.1.205 NADH
-
Rattus norvegicus
1.1.1.205 ribavirin 5'-monophosphate
-
Rattus norvegicus
1.1.1.205 thiazole-4-carboxamide adenine dinucleotide
-
Rattus norvegicus
1.1.1.205 xanthosine 5'-phosphate competitive inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.205 0.023
-
IMP
-
Rattus norvegicus
1.1.1.205 0.065
-
NAD+
-
Rattus norvegicus
1.1.1.205 7.8
-
K+
-
Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.205 60000
-
4 * 60000, rat hepatoma 3924 A cells, SDS-PAGE Rattus norvegicus
1.1.1.205 245000
-
rat hepatoma 3924 A cells, gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Rattus norvegicus
-
hepatoma 3924A
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.205 hepatoma cells 3924 A Rattus norvegicus
1.1.1.205 homogeneitiy Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.205 IMP + NAD+ + H2O = XMP + NADH + H+ enzyme acts on the hydroxyl group of the hydrated derivative of the substrate, ordered bi-bi mechanism Rattus norvegicus
1.1.1.205 IMP + NAD+ + H2O = XMP + NADH + H+ IMP binds first, followed by NAD+, NADH dissociates from the ternary complex first, then XMP is released Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.205 Morris hepatoma 3924A cell
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.205 1.7
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.1.1.205 -70°C, 10 mg/ml bovine serum albumin, 3 weeks, 15% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 inosine 5'-phosphate + NAD+ + H2O
-
Rattus norvegicus xanthosine 5'-phosphate + NADH
-
?

Subunits

EC Number Subunits Comment Organism
1.1.1.205 tetramer 4 * 60000, rat hepatoma 3924 A cells, SDS-PAGE Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 0.0008
-
ribavirin 5'-monophosphate
-
Rattus norvegicus
1.1.1.205 0.0013
-
thiazole-4-carboxamide adenine dinucleotide
-
Rattus norvegicus
1.1.1.205 0.136
-
xanthosine 5'-phosphate
-
Rattus norvegicus
1.1.1.205 0.21
-
NADH
-
Rattus norvegicus