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Literature summary extracted from

  • Chung, H.; Harvey, R.G.; Armstrong, R.N.; Jarabak, J.
    Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase (1987), J. Biol. Chem., 262, 12448-12451.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.197 1-glutathionyl-2-hydroxy-3(allyloxy)propane competitive inhibition of prostaglandin B1 oxidation Homo sapiens
1.1.1.197 glutathione-9-hydroxy-prostaglandin A1 thioether inhibition of polycyclic aromatic hydrocarbon quinone reduction Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.197 0.00018
-
 4,5-benzo[a]pyrenequinone
-
 Homo sapiens
1.1.1.197 0.00033
-
 glutathione-prostaglandin A1 thioether
-
 Homo sapiens
1.1.1.197 0.00036
-
 9,10-phenanthrenequinone
-
 Homo sapiens
1.1.1.197 0.00051
-
 5,6-chrysenequinone
-
 Homo sapiens
1.1.1.197 0.00087
-
 7,8-benzo[a]pyrenequinone
-
 Homo sapiens
1.1.1.197 0.0024
-
 2-methyl-3-glutathionyl-1,4-benzoquinone
-
 Homo sapiens
1.1.1.197 0.0034
-
 2-methyl-3-glutathionyl-1,4-naphthoquinone
-
 Homo sapiens
1.1.1.197 0.0076
-
 menadione
-
 Homo sapiens
1.1.1.197 0.03
-
 toluquinone
-
 Homo sapiens
1.1.1.197 0.09
-
 prostaglandin A1
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.197 Homo sapiens
-
 human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.197
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.197 placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.197 0.09
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.197 2-methyl-3-glutathionyl-1,4-benzoquinone + NADPH toluquinone thioether Homo sapiens ? + NADP+
-
 ?
1.1.1.197 2-methyl-3-glutathionyl-1,4-naphthoquinone + NADPH menadione thioether Homo sapiens ? + NADP+
-
 ?
1.1.1.197 4,5-benzo[a]pyrenequinone + NADPH
-
 Homo sapiens ? + NADP+
-
 ?
1.1.1.197 5,6-chrysenequinone + NADPH
-
 Homo sapiens ? + NADP+
-
 ?
1.1.1.197 7,8-benzo[a]pyrenequinone + NADPH
-
 Homo sapiens ? + NADP+
-
 ?
1.1.1.197 9,10-phenanthrenequinone + NADPH
-
 Homo sapiens ? + NADP+
-
 ?
1.1.1.197 glutathione-9-hydroxy-prostaglandin A1 thioether + NADP+
-
 Homo sapiens ? + NADPH
-
 ?
1.1.1.197 glutathione-prostaglandin A1 thioether + NADP+ PGA1-SG, excellent substrate for the placental enzyme Homo sapiens ? + NADPH
-
 ?
1.1.1.197 menadione + NADPH
-
 Homo sapiens ? + NADP+
-
 ?
1.1.1.197 additional information the trans-dihydrodiols trans-dihydroxy-4,5-dihydrobenzo[alpha]pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene, trans-3,4-dihydroxy-3,4-dihydrobenz[alpha]anthracene and its 7-methyl, 12-methyl, and 7,12-dimethyl derivatives are not substrates for the enzyme Homo sapiens ?
-
 ?
1.1.1.197 prostaglandin A1 + NADP+
-
 Homo sapiens 15-oxoprostaglandin A1 + NADPH + H+
-
 ?
1.1.1.197 prostaglandin B1 + NADP+
-
 Homo sapiens 15-oxoprostaglandin B1 + NADPH + H+
-
 ?
1.1.1.197 toluquinone + NADPH
-
 Homo sapiens ? + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.197 9-ketoprostaglandin reductase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.197 NADP+
-
 Homo sapiens