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Literature summary extracted from

  • Watanabe, K.; Shimizu, T.; Iguchi, S.; Wakatsuka, H.; Hayashi, M.; Hayaishi, O.
    An NADP-linked prostaglandin D dehydrogenase in swine brain (1980), J. Biol. Chem., 255, 1779-1782.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.196 0.0005
-
NADP+
-
Sus scrofa
1.1.1.196 0.07
-
Prostaglandin D2
-
Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.196 62000
-
-
Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.196 Sus scrofa
-
swine
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.196 partially Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.196 brain
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.196 0.001795
-
-
Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.196 prostaglandin A2 + NADP+ poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2 Sus scrofa 15-ketoprostaglandin A2 + NADPH + H+
-
?
1.1.1.196 prostaglandin B2 + NADP+ poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2 Sus scrofa 15-ketoprostaglandin B2 + NADPH + H+
-
?
1.1.1.196 prostaglandin D2 + NADP+
-
Sus scrofa 15-ketoprostaglandin D2 + NADPH + H+
-
?
1.1.1.196 prostaglandin D3 + NADP+ poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2 Sus scrofa 15-ketoprostaglandin D3 + NADPH + H+
-
?
1.1.1.196 prostaglandin E2 + NADP+ poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2 Sus scrofa 15-ketoprostaglandin E2 + NADPH + H+
-
?
1.1.1.196 prostaglandin F2alpha + NADP+ poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2 Sus scrofa 15-ketoprostaglandin F2alpha + NADPH + H+
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.196 24
-
enzyme assay Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.196 NAD+ activity less than 1% of that with NADP+ Sus scrofa