EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.1.1.168 | - |
Candida parapsilosis |
1.1.1.358 | - |
Candida parapsilosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.168 | 3,4-Dihydroxy-3-cyclobutene-1,2-dione | uncompetitive to isatin | Candida parapsilosis | |
1.1.1.168 | Al3+ | - |
Candida parapsilosis | |
1.1.1.168 | Cd2+ | - |
Candida parapsilosis | |
1.1.1.168 | Cu2+ | - |
Candida parapsilosis | |
1.1.1.168 | Hg2+ | - |
Candida parapsilosis | |
1.1.1.168 | iodoacetate | - |
Candida parapsilosis | |
1.1.1.168 | ketopantoyl lactone | competitive to isatin | Candida parapsilosis | |
1.1.1.168 | p-chloromercuribenzoate | - |
Candida parapsilosis | |
1.1.1.168 | Polyketones | cyclohexenediol-1,2,3,4-tetraone; e.g. parabanic acid | Candida parapsilosis | |
1.1.1.168 | quercetin | - |
Candida parapsilosis | |
1.1.1.168 | Zn2+ | - |
Candida parapsilosis | |
1.1.1.358 | 2-dehydropantolactone | competitive versus isatin | Candida parapsilosis | |
1.1.1.358 | 3,4-Dihydroxy-3-cyclobutene-1,2-dione | uncompetitive | Candida parapsilosis | |
1.1.1.358 | Al3+ | 83%% inhibition, reduction of 2-dehydropantolactone | Candida parapsilosis | |
1.1.1.358 | Cd2+ | 97% inhibition, reduction of 2-dehydropantolactone | Candida parapsilosis | |
1.1.1.358 | Cu2+ | completely inhibits reduction of 2-dehydropantolactone | Candida parapsilosis | |
1.1.1.358 | cyclohexenediol-1,2,3,4-tetraone | uncompetitive | Candida parapsilosis | |
1.1.1.358 | Hg2+ | completely inhibits reduction of 2-dehydropantolactone | Candida parapsilosis | |
1.1.1.358 | iodoacetate | 1 mM, 49% inhibition | Candida parapsilosis | |
1.1.1.358 | p-chloromercuribenzoate | 0.1 mM, 72% inhibition | Candida parapsilosis | |
1.1.1.358 | parabanic acid | uncompetitive | Candida parapsilosis | |
1.1.1.358 | quercetin | 0.1 mM, 94% inhibition | Candida parapsilosis | |
1.1.1.358 | Zn2+ | completely inhibits reduction of 2-dehydropantolactone | Candida parapsilosis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.168 | 0.014 | - |
isatin | - |
Candida parapsilosis | |
1.1.1.168 | 0.016 | - |
5-methylisatin | - |
Candida parapsilosis | |
1.1.1.168 | 0.085 | - |
1-methylisatin | - |
Candida parapsilosis | |
1.1.1.168 | 0.333 | - |
ketopantoyl lactone | - |
Candida parapsilosis | |
1.1.1.358 | 0.014 | - |
isatin | pH 7.0, 30°C | Candida parapsilosis | |
1.1.1.358 | 0.016 | - |
5-methylisatin | pH 7.0, 30°C | Candida parapsilosis | |
1.1.1.358 | 0.085 | - |
1-methylisatin | pH 7.0, 30°C | Candida parapsilosis | |
1.1.1.358 | 0.333 | - |
2-dehydropantolactone | pH 7.0, 30°C | Candida parapsilosis |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.168 | 39000 | - |
gel filtration | Candida parapsilosis |
1.1.1.168 | 41600 | - |
1 * 41600, SDS-PAGE | Candida parapsilosis |
1.1.1.358 | 31000 | - |
gel filtration | Candida parapsilosis |
1.1.1.358 | 40000 | - |
polyacrylamide gel electrophoresis | Candida parapsilosis |
1.1.1.358 | 41600 | - |
1 * 41600, SDS-PAGE | Candida parapsilosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.168 | 2-dehydropantoyl lactone + NADPH | Candida parapsilosis | - |
(R)-pantoyl lactone + NADP+ | - |
ir | |
1.1.1.168 | 2-dehydropantoyl lactone + NADPH | Candida parapsilosis IFO 0708 | - |
(R)-pantoyl lactone + NADP+ | - |
ir | |
1.1.1.358 | 2-dehydropantolactone + NADPH + H+ | Candida parapsilosis | - |
(R)-pantolactone + NADP+ | - |
ir |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.168 | Candida parapsilosis | - |
IFO 0708 | - |
1.1.1.358 | Candida parapsilosis | - |
- |
- |
1.1.1.358 | Candida parapsilosis IFO 0708 | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.168 | IFO 0708 | Candida parapsilosis |
1.1.1.358 | - |
Candida parapsilosis |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.168 | 173 | - |
ketopantoyl lactone | Candida parapsilosis |
1.1.1.168 | 251 | - |
isatin | Candida parapsilosis |
1.1.1.358 | 173 | - |
pH 7.0, 30°C, substrate: 2-dehydropantolactone | Candida parapsilosis |
1.1.1.358 | 251 | - |
pH 7.0, 30°C, substrate: isatin | Candida parapsilosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.168 | 1-methylisatin + NADPH | - |
Candida parapsilosis | ? | - |
? | |
1.1.1.168 | 2-dehydropantoyl lactone + NADPH | - |
Candida parapsilosis | (R)-pantoyl lactone + NADP+ | - |
ir | |
1.1.1.168 | 2-dehydropantoyl lactone + NADPH | - |
Candida parapsilosis IFO 0708 | (R)-pantoyl lactone + NADP+ | - |
ir | |
1.1.1.168 | 5-methylisatin + NADPH | - |
Candida parapsilosis | ? | - |
? | |
1.1.1.168 | camphorquinone + NADPH | - |
Candida parapsilosis | ? | - |
? | |
1.1.1.168 | camphorquinone + NADPH | - |
Candida parapsilosis IFO 0708 | ? | - |
? | |
1.1.1.168 | isatin + NADPH | and its derivatives | Candida parapsilosis | ? | - |
? | |
1.1.1.168 | isatin + NADPH | and its derivatives | Candida parapsilosis IFO 0708 | ? | - |
? | |
1.1.1.168 | additional information | carbonyl reductase specifically catalyzing the reduction of conjugated polyketones | Candida parapsilosis | additional information | - |
? | |
1.1.1.168 | additional information | carbonyl reductase specifically catalyzing the reduction of conjugated polyketones | Candida parapsilosis IFO 0708 | additional information | - |
? | |
1.1.1.168 | naphthoquinone + NADPH | - |
Candida parapsilosis | ? | - |
? | |
1.1.1.168 | naphthoquinone + NADPH | - |
Candida parapsilosis IFO 0708 | ? | - |
? | |
1.1.1.358 | 1-methylisatin + NADPH + H+ | 86% of the activity compared to isatin | Candida parapsilosis | ? | - |
? | |
1.1.1.358 | 2-dehydropantolactone + NADPH + H+ | - |
Candida parapsilosis | (R)-pantolactone + NADP+ | - |
ir | |
1.1.1.358 | 2-dehydropantolactone + NADPH + H+ | 69% of the activity compared to isatin. The stereospecificity for NADPH is not known. Activity with NADH is 2% compared to the activity with NADPH | Candida parapsilosis | (R)-pantolactone + NADP+ | - |
ir | |
1.1.1.358 | 5-methylisatin + NADPH + H+ | 108% of the activity compared to isatin | Candida parapsilosis | ? | - |
? | |
1.1.1.358 | camphorquinone + NADPH + H+ | 97% of the activity compared to isatin | Candida parapsilosis | ? | - |
? | |
1.1.1.358 | isatin + NADPH + H+ | - |
Candida parapsilosis | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.168 | monomer | 1 * 41600, SDS-PAGE | Candida parapsilosis |
1.1.1.358 | monomer | 1 * 41600, SDS-PAGE | Candida parapsilosis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.358 | ketopantoyl-lactone reductase | - |
Candida parapsilosis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.168 | 30 | - |
assay at | Candida parapsilosis |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.168 | 40 | - |
pH 7.0, 10 min, 58% loss of activity | Candida parapsilosis |
1.1.1.168 | 60 | - |
pH 7.0, 10 min, 77% loss of activity | Candida parapsilosis |
1.1.1.358 | 40 | - |
pH 7.0, 10 min, 58% loss of activity | Candida parapsilosis |
1.1.1.358 | 60 | - |
pH 7.0, 10 min, 77% loss of activity | Candida parapsilosis |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.168 | 4 | - |
30°C, 30 min, 33% loss of activity | Candida parapsilosis |
1.1.1.168 | 6 | 10 | - |
Candida parapsilosis |
1.1.1.358 | 4 | - |
30°C, 30 min, 33% loss of activity | Candida parapsilosis |
1.1.1.358 | 6 | 10 | enzyme is stable | Candida parapsilosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.358 | NADPH | activity with NADH is 2% compared to the activity with NADPH | Candida parapsilosis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.358 | 0.0002 | - |
cyclohexenediol-1,2,3,4-tetraone | pH 7.0, 30°C, substrate: isatin | Candida parapsilosis | |
1.1.1.358 | 0.0014 | - |
3,4-Dihydroxy-3-cyclobutene-1,2-dione | pH 7.0, 30°C, substrate: isatin | Candida parapsilosis | |
1.1.1.358 | 0.19 | - |
2-dehydropantolactone | pH 7.0, 30°C, substrate: isatin | Candida parapsilosis | |
1.1.1.358 | 3.14 | - |
parabanic acid | pH 7.0, 30°C, substrate: isatin | Candida parapsilosis |
EC Number | Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|---|
1.1.1.358 | Candida parapsilosis | electrofocussing | - |
6.3 |