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Literature summary extracted from

  • Morinaga, Y.; Tani, Y.; Yamada, H.
    Biosynthesis of homocysteine in a facultative methylotroph, Pseudomonas FM518 (1983), Agric. Biol. Chem., 47, 2855-2860.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.49 L-methionine competitive inhibition Pseudomonas sp.
2.5.1.49 S-adenosyl-L-methionine
-
 Pseudomonas sp.
4.4.1.13 L-Met competitive Pseudomonas sp.
4.4.1.13 S-adenosylmethionine weak Pseudomonas sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.49 3.6
-
 O-acetyl-L-serine
-
 Pseudomonas sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.49 O-acetyl-L-homoserine + H2S Pseudomonas sp. direct sulfhydrylation pathway, biosynthesis of homocysteine L-homocysteine + acetic acid
-
 ?
2.5.1.49 O-acetyl-L-homoserine + H2S Pseudomonas sp. FM518 direct sulfhydrylation pathway, biosynthesis of homocysteine L-homocysteine + acetic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.49 Pseudomonas sp.
-
 FM518
-
2.5.1.49 Pseudomonas sp. FM518
-
 FM518
-
4.4.1.13 Pseudomonas sp.
-
 FM518
-
4.4.1.13 Pseudomonas sp. FM518
-
 FM518
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.49 additional information L-homoserine and O-succinyl-L-homoserine are no substrates Pseudomonas sp. ?
-
 ?
2.5.1.49 additional information L-homoserine and O-succinyl-L-homoserine are no substrates Pseudomonas sp. FM518 ?
-
 ?
2.5.1.49 O-acetyl-L-homoserine + H2S
-
 Pseudomonas sp. L-homocysteine + acetic acid
-
 ?
2.5.1.49 O-acetyl-L-homoserine + H2S direct sulfhydrylation pathway, biosynthesis of homocysteine Pseudomonas sp. L-homocysteine + acetic acid
-
 ?
2.5.1.49 O-acetyl-L-homoserine + H2S
-
 Pseudomonas sp. FM518 L-homocysteine + acetic acid
-
 ?
2.5.1.49 O-acetyl-L-homoserine + H2S direct sulfhydrylation pathway, biosynthesis of homocysteine Pseudomonas sp. FM518 L-homocysteine + acetic acid
-
 ?
2.5.1.49 O-acetyl-L-serine
-
 Pseudomonas sp. L-cysteine + acetate
-
 ?
2.5.1.49 O-acetyl-L-serine
-
 Pseudomonas sp. FM518 L-cysteine + acetate
-
 ?
4.4.1.13 L-cystathionine + H2O
-
 Pseudomonas sp. L-homocysteine + NH3 + pyruvate
-
 ?
4.4.1.13 L-cystathionine + H2O
-
 Pseudomonas sp. FM518 L-homocysteine + NH3 + pyruvate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.49 OAH
-
 Pseudomonas sp.

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.13 pyridoxal 5'-phosphate required as cofactor Pseudomonas sp.

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.49 1.6
-
 L-methionine O-acetylserine sulfhydrylase activity Pseudomonas sp.
2.5.1.49 15
-
 L-methionine O-acetylhomoserine sulfhydrylase activity Pseudomonas sp.