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Literature summary extracted from

  • McKie, A.E.; Edlind, T.; Walker, J.; Mottram, J.C.; Coombs, G.H.
    The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5 -phosphate-dependent enzymes (1998), J. Biol. Chem., 273, 5549-5556.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
4.4.1.11 C113G MGL1, reduced activity towards methionine and homocysteine Trichomonas vaginalis
4.4.1.11 C116G MGL2, reduced activity towards methionine and homocysteine Trichomonas vaginalis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.11 3.6
-
 cysteine recombinant, MGL2 C116G Trichomonas vaginalis
4.4.1.11 4.3
-
 L-methionine
-
 Trichomonas vaginalis
4.4.1.11 6.2
-
 L-ethionine recombinant MGL2, C116G Trichomonas vaginalis
4.4.1.11 8.5
-
 cysteine recombinant MGL1 Trichomonas vaginalis
4.4.1.11 9.7
-
 cysteine recombinant MGL1, C113G Trichomonas vaginalis
4.4.1.11 12.2
-
 L-ethionine recombinant MGL1 Trichomonas vaginalis
4.4.1.11 15.2
-
 L-ethionine recombinant MGL1, C113G Trichomonas vaginalis
4.4.1.11 22.3
-
 cysteine recombinant MGL2 Trichomonas vaginalis
4.4.1.11 37.2
-
 L-ethionine recombinant MGL2 Trichomonas vaginalis

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.11 Trichomonas vaginalis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.11 L-cysteine + H2O
-
 Trichomonas vaginalis ?
-
 ?
4.4.1.11 L-ethionine + H2O
-
 Trichomonas vaginalis ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.11 pyridoxal 5'-phosphate
-
 Trichomonas vaginalis