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Literature summary extracted from

  • Camm, E.L.; Towers, G.H.N.
    Phenylalanine ammonia lyase (1973), Phytochemistry, 12, 961-973.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.24 4-coumarate
-
 Rhodotorula glutinis
4.3.1.24 4-coumarate
-
 Ustilago hordei
4.3.1.24 Cinnamic acid
-
 Avena sativa
4.3.1.24 Cinnamic acid
-
 Hordeum vulgare
4.3.1.24 Cinnamic acid
-
 Solanum tuberosum
4.3.1.24 Cinnamic acid
-
 Sporobolomyces roseus
4.3.1.24 Cinnamic acid
-
 Streptomyces verticillatus
4.3.1.24 Cinnamic acid
-
 Ustilago hordei
4.3.1.24 CN-
-
 Hordeum vulgare
4.3.1.24 CN- irreversible Nicotiana tabacum
4.3.1.24 CN- irreversible Rhodotorula glutinis
4.3.1.24 CN- irreversible Solanum tuberosum
4.3.1.24 CN- irreversible Streptomyces verticillatus
4.3.1.24 D-Phe
-
 Rhodotorula glutinis
4.3.1.24 D-Phe
-
 Solanum tuberosum
4.3.1.24 fluorophenylalanine
-
 Avena sativa
4.3.1.24 fluorophenylalanine
-
 Ipomoea batatas
4.3.1.24 fluorophenylalanine
-
 Streptomyces verticillatus
4.3.1.24 His
-
 Streptomyces verticillatus
4.3.1.24 NaBH4 irreversible Nicotiana tabacum
4.3.1.24 NaBH4 irreversible Rhodotorula glutinis
4.3.1.24 NaBH4 irreversible Solanum tuberosum
4.3.1.24 NaBH4 irreversible Streptomyces verticillatus
4.3.1.24 o-coumarate
-
 Nicotiana tabacum
4.3.1.24 Tyr
-
 Hordeum vulgare
4.3.1.24 Tyr
-
 Ipomoea batatas
4.3.1.24 Tyr
-
 Nicotiana tabacum
4.3.1.25 4-coumarate
-
 Sporidiobolus pararoseus
4.3.1.25 Cinnamic acid
-
 Sporidiobolus pararoseus
4.3.1.25 CN-
-
 Sporidiobolus pararoseus
4.3.1.25 fluorophenylalanine
-
 Triticum aestivum
4.3.1.25 Tyr D-Tyr; m-Try Triticum aestivum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.1.24 0.03
-
 L-Phe tissue culture Nicotiana tabacum
4.3.1.24 0.052
-
 L-Phe at low substrate concentrations Pisum sativum
4.3.1.24 0.16
-
 L-Phe
-
 Streptomyces verticillatus
4.3.1.24 0.22
-
 L-Phe
-
 Nicotiana tabacum
4.3.1.24 0.4
-
 L-Phe
-
 Sporobolomyces roseus
4.3.1.24 0.45
-
 L-Phe
-
 Ustilago hordei
4.3.1.24 0.8
-
 L-Phe at high substrate concentrationas Pisum sativum
4.3.1.24 2.1
-
 L-Phe
-
 Rhodotorula glutinis
4.3.1.24 15
-
 L-Phe
-
 Rhodotorula texensis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.1.24 226000
-
-
 Streptomyces verticillatus
4.3.1.24 330000
-
-
 Solanum tuberosum

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.24 Avena sativa
-
-
-
4.3.1.24 Hordeum vulgare
-
-
-
4.3.1.24 Ipomoea batatas
-
-
-
4.3.1.24 Nicotiana tabacum
-
-
-
4.3.1.24 Pisum sativum
-
-
-
4.3.1.24 Pteridium aquilinum
-
-
-
4.3.1.24 Quercus pedunculata
-
-
-
4.3.1.24 Rhodotorula glutinis
-
-
-
4.3.1.24 Rhodotorula texensis
-
-
-
4.3.1.24 Solanum tuberosum
-
 2 enzyme forms which are not interconvertible
-
4.3.1.24 Sporobolomyces roseus
-
-
-
4.3.1.24 Streptomyces verticillatus
-
-
-
4.3.1.24 Tulipa hybrid cultivar
-
-
-
4.3.1.24 Ustilago hordei
-
-
-
4.3.1.25 Sporidiobolus pararoseus
-
-
-
4.3.1.25 Triticum aestivum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.1.24 anther
-
 Tulipa hybrid cultivar
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.24 chlorophenylalanine
-
 Streptomyces verticillatus ?
-
 ?
4.3.1.24 fluorophenylalanine
-
 Streptomyces verticillatus trans-(4-fluoro)cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Hordeum vulgare (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Pisum sativum (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Solanum tuberosum (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Nicotiana tabacum (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Avena sativa (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Rhodotorula glutinis (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Tulipa hybrid cultivar (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Streptomyces verticillatus (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Rhodotorula texensis (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Sporobolomyces roseus (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Ustilago hordei (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Pteridium aquilinum (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Ipomoea batatas (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-Phe
-
 Quercus pedunculata (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-tyrosine
-
 Rhodotorula glutinis p-coumarate + NH3
-
 ?
4.3.1.24 L-tyrosine no activity Solanum tuberosum p-coumarate + NH3
-
 ?
4.3.1.24 L-tyrosine no activity Nicotiana tabacum p-coumarate + NH3
-
 ?
4.3.1.24 L-tyrosine no activity Streptomyces verticillatus p-coumarate + NH3
-
 ?
4.3.1.24 L-tyrosine no activity Ustilago hordei p-coumarate + NH3
-
 ?
4.3.1.24 L-tyrosine no activity Pteridium aquilinum p-coumarate + NH3
-
 ?
4.3.1.25 L-Phe
-
 Triticum aestivum (E)-cinnamate + NH3
-
 ?
4.3.1.25 L-Phe
-
 Sporidiobolus pararoseus (E)-cinnamate + NH3
-
 ?
4.3.1.25 L-tyrosine
-
 Triticum aestivum p-coumarate + NH3
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.3.1.24 8 8.6
-
 Nicotiana tabacum
4.3.1.24 8.5
-
-
 Streptomyces verticillatus
4.3.1.24 8.5 9.5
-
 Ipomoea batatas
4.3.1.24 8.7
-
-
 Solanum tuberosum
4.3.1.24 8.7
-
-
 Sporobolomyces roseus
4.3.1.24 8.8
-
-
 Ustilago hordei
4.3.1.24 8.8
-
 tissue culture Nicotiana tabacum
4.3.1.24 9
-
-
 Rhodotorula glutinis
4.3.1.24 9
-
-
 Rhodotorula texensis