EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
5.4.3.8 | ethanolamine | stimulates activity of mutant enzyme Lys265Arg | Escherichia coli | |
5.4.3.8 | methylamine | stimulates activity of mutant enzyme Lys265Arg | Escherichia coli |
EC Number | Cloned (Comment) | Organism |
---|---|---|
5.4.3.8 | mutant enzyme Lys265Arg, overexpression | Escherichia coli |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
5.4.3.8 | L265E | mutant Lys265Arg has 2% of the enzymatic activity compared to the wild-type enzyme, the dimeric structure is not influenced, activity is stimulated by addition of exogenous amines such as ethanolamine and methylamine | Escherichia coli |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.4.3.8 | (S)-4-Amino-5-oxopentanoate | Escherichia coli | 4,5-dioxovalerate and 4,5-diaminovalerate are reaction intermediates | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.4.3.8 | Escherichia coli | - |
wild-type and active site mutant K265R | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.4.3.8 | (S)-4-Amino-5-oxopentanoate | - |
Escherichia coli | 5-Amino-4-oxopentanoate | - |
? | |
5.4.3.8 | (S)-4-Amino-5-oxopentanoate | 4,5-dioxovalerate and 4,5-diaminovalerate are reaction intermediates | Escherichia coli | ? | - |
? | |
5.4.3.8 | 4,5-Diaminovalerate | is a substrate for the pyridoxal 5'-phosphate form of the enzyme | Escherichia coli | ? | - |
? | |
5.4.3.8 | 4,5-Dioxovalerate | is a substrate for the pyridoxamine form of the enzyme | Escherichia coli | 5-Amino-4-oxopentanoate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
5.4.3.8 | dimer | - |
Escherichia coli |