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Literature summary extracted from

  • Brand, L.M.; Harper, A.E.
    Histidine ammonia-lyase from rat liver. Purification, properties, and inhibition by substrate analogues (1976), Biochemistry, 15, 1814-1821.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.3 4-nitro-L-histidine competitive Pseudomonas fluorescens
4.3.1.3 5-fluoro-L-histidine competitive Pseudomonas fluorescens
4.3.1.3 D-alpha-hydrazinoimidazolylpropionic acid strong Rattus norvegicus
4.3.1.3 D-histidine competitive Pseudomonas fluorescens
4.3.1.3 D-histidine competitive Rattus norvegicus
4.3.1.3 DL-pyrazolyl-3-alanine 5.0 mM Rattus norvegicus
4.3.1.3 glycine
-
 Rattus norvegicus
4.3.1.3 L-1-methylhistidine 5.0 mM Rattus norvegicus
4.3.1.3 L-alanine 5.0 mM Rattus norvegicus
4.3.1.3 L-histidine hydroxamate competitive; strong Rattus norvegicus
4.3.1.3 L-histidinemethyl ester 5.0 mM Rattus norvegicus
4.3.1.3 L-histidinol competitive Rattus norvegicus
4.3.1.3 additional information
-
 Rattus norvegicus
4.3.1.3 N-acetyl-L-histidine 5.0 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.1.3 additional information
-
 additional information
-
 Rattus norvegicus
4.3.1.3 additional information
-
 additional information
-
 Pseudomonas fluorescens
4.3.1.3 0.45
-
 L-histidine pH 9.0 Rattus norvegicus
4.3.1.3 2.1
-
 L-histidine pH 7.2 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.1.3 203000
-
 disc gel electrophoresis Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.3 Pseudomonas fluorescens
-
-
-
4.3.1.3 Rattus norvegicus
-
 Holtzman albion rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.1.3
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
4.3.1.3 L-histidine = urocanate + NH3 mechanism Rattus norvegicus
a
4.3.1.3 L-histidine = urocanate + NH3 mechanism Pseudomonas fluorescens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.1.3 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3.1.3 9.94
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.3 4-fluorohistidine
-
 Pseudomonas fluorescens 4-fluorourocanate + NH3
-
 ?
4.3.1.3 4-nitro-L-histidine
-
 Pseudomonas fluorescens 4-nitrourocanate + NH3
-
 ?
4.3.1.3 L-histidine natural substrate Rattus norvegicus urocanate + NH3
-
 ?
4.3.1.3 L-histidine natural substrate Pseudomonas fluorescens urocanate + NH3
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.3.1.3 8.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.3.1.3 6.5 10 inactive below pH 6.5, 75% of maximal activity at pH 10.0 Rattus norvegicus