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Literature summary extracted from

  • Okamura, H.; Nishida, T.; Nakagawa, H.
    L-histidine ammonia-lyase in rat liver. I. Purification and general characteristics (1974), J. Biochem., 75, 139-152.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.3.1.3 2-mercaptoethanol activates at concentrations up to 10 mM Rattus norvegicus
4.3.1.3 GSH
-
Cavia porcellus
4.3.1.3 GSH activates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.3 2-mercaptoethanol inhibition at concentrations above 10 mM, reversed by addition of metal ion Rattus norvegicus
4.3.1.3 dithiothreitol
-
Cavia porcellus
4.3.1.3 dithiothreitol
-
Rattus norvegicus
4.3.1.3 EDTA
-
Cavia porcellus
4.3.1.3 EDTA
-
Rattus norvegicus
4.3.1.3 additional information
-
Rattus norvegicus
4.3.1.3 NaBH4
-
Rattus norvegicus
4.3.1.3 Nitromethane
-
Rattus norvegicus
4.3.1.3 p-mercuribenzoate 0.01 mM, complete inhibition, partially reversed by addition of histidine Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.1.3 1.2
-
L-histidine
-
Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.3.1.3 Ca2+ activates at a concentration of 0.1 mM Rattus norvegicus
4.3.1.3 Cd2+ activates at a concentration of 0.1 mM Rattus norvegicus
4.3.1.3 Mg2+ activates at a concentration of 0.1 mM Rattus norvegicus
4.3.1.3 Mn2+ activates at a concentration of 0.1 mM Rattus norvegicus
4.3.1.3 Ni2+ activates at a concentration of 0.1 mM Rattus norvegicus
4.3.1.3 Zn2+
-
Cavia porcellus
4.3.1.3 Zn2+ activates at a concentration of 0.1 mM Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.1.3 190000
-
sedimentation equilibrium Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.3 Cavia porcellus
-
-
-
4.3.1.3 Rattus norvegicus
-
female Spargue-Dawley
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.1.3
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.1.3 liver
-
Cavia porcellus
-
4.3.1.3 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3.1.3 additional information
-
-
Cavia porcellus
4.3.1.3 additional information
-
-
Rattus norvegicus
4.3.1.3 6.8
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
4.3.1.3 0°C, 24 h, pH 3.0 or pH 12.0, complete loss of activity Rattus norvegicus
4.3.1.3 0°C, 24 h, pH 7.0-10.0, enzyme retains full activity Rattus norvegicus
4.3.1.3 0°C, complete loss of activity within 1 week Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.3 L-histidine natural substrate Cavia porcellus urocanate + NH3
-
?
4.3.1.3 L-histidine natural substrate Rattus norvegicus urocanate + NH3
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.3.1.3 8.8 9
-
Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.3.1.3 7 10 pH 7.0: 10% of maximal activity, pH 10: about 50% of maximal activity Rattus norvegicus