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Literature summary extracted from

  • Daniel, R.; Bobik, T.A.; Gottschalk, G.
    Biochemistry of coenzyme B-12-dependent glycerol and diol dehydratases and organization of the encoding genes (1999), FEMS Microbiol. Rev., 22, 553-566.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.30 NH4+
-
 Lactobacillus sp.
4.2.1.30 NH4+ activates Klebsiella pneumoniae
4.2.1.30 NH4+ activates Citrobacter freundii

Application

EC Number Application Comment Organism
4.2.1.30 synthesis 1,3-propanediol, starting material for producing plastics, from glycerol relies on the activity of glycerol or diol dehydratases Klebsiella pneumoniae
4.2.1.30 synthesis 1,3-propanediol, starting material for producing plastics, from glycerol relies on the activity of glycerol or diol dehydratases Citrobacter freundii

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.30 glycerol
-
 Citrobacter freundii
4.2.1.30 glycerol
-
 Klebsiella pneumoniae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.30 K+
-
 Lactobacillus sp.
4.2.1.30 K+ activates Klebsiella pneumoniae
4.2.1.30 K+ activates Citrobacter freundii
4.2.1.30 Rb+
-
 Lactobacillus sp.
4.2.1.30 Rb+ activates Klebsiella pneumoniae
4.2.1.30 Rb+ activates Citrobacter freundii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.30 16121
-
 alpha2,beta2,gamma2, 2 * 60433 + 2 * 21487 + 2 * 16121, calculation from sequence of amino acid Citrobacter freundii
4.2.1.30 16722
-
 alpha2,beta2,gamma2, 2 * 60813 + 2 * 19549 + 2 * 16722, calculation from sequence of amino acid Clostridium pasteurianum
4.2.1.30 19549
-
 alpha2,beta2,gamma2, 2 * 60813 + 2 * 19549 + 2 * 16722, calculation from sequence of amino acid Clostridium pasteurianum
4.2.1.30 21487
-
 alpha2,beta2,gamma2, 2 * 60433 + 2 * 21487 + 2 * 16121, calculation from sequence of amino acid Citrobacter freundii
4.2.1.30 60433
-
 alpha2,beta2,gamma2, 2 * 60433 + 2 * 21487 + 2 * 16121, calculation from sequence of amino acid Citrobacter freundii
4.2.1.30 60813
-
 alpha2,beta2,gamma2, 2 * 60813 + 2 * 19549 + 2 * 16722, calculation from sequence of amino acid Clostridium pasteurianum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.30 glycerol Klebsiella pneumoniae
-
 ?
-
 ?
4.2.1.30 glycerol Pantoea agglomerans
-
 ?
-
 ?
4.2.1.30 glycerol Clostridium pasteurianum
-
 ?
-
 ?
4.2.1.30 glycerol Levilactobacillus brevis
-
 ?
-
 ?
4.2.1.30 glycerol Lactobacillus sp.
-
 ?
-
 ?
4.2.1.30 glycerol Clostridium butyricum
-
 ?
-
 ?
4.2.1.30 glycerol Citrobacter freundii
-
 ?
-
 ?
4.2.1.30 glycerol Lentilactobacillus buchneri
-
 ?
-
 ?
4.2.1.30 glycerol Limosilactobacillus reuteri
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.30 Citrobacter freundii
-
-
-
4.2.1.30 Clostridium butyricum
-
-
-
4.2.1.30 Clostridium pasteurianum
-
-
-
4.2.1.30 Klebsiella pneumoniae
-
-
-
4.2.1.30 Lactobacillus sp.
-
-
-
4.2.1.30 Lentilactobacillus buchneri
-
-
-
4.2.1.30 Levilactobacillus brevis
-
-
-
4.2.1.30 Limosilactobacillus reuteri
-
-
-
4.2.1.30 Pantoea agglomerans
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.2.1.30 glycerol = 3-hydroxypropanal + H2O mechanism of enzyme reaction Klebsiella pneumoniae
a
4.2.1.30 glycerol = 3-hydroxypropanal + H2O mechanism of enzyme reaction Pantoea agglomerans
a
4.2.1.30 glycerol = 3-hydroxypropanal + H2O mechanism of enzyme reaction Clostridium pasteurianum
a
4.2.1.30 glycerol = 3-hydroxypropanal + H2O mechanism of enzyme reaction Levilactobacillus brevis
a
4.2.1.30 glycerol = 3-hydroxypropanal + H2O mechanism of enzyme reaction Lactobacillus sp.
a
4.2.1.30 glycerol = 3-hydroxypropanal + H2O mechanism of enzyme reaction Clostridium butyricum
a
4.2.1.30 glycerol = 3-hydroxypropanal + H2O mechanism of enzyme reaction Citrobacter freundii
a
4.2.1.30 glycerol = 3-hydroxypropanal + H2O mechanism of enzyme reaction Lentilactobacillus buchneri
a
4.2.1.30 glycerol = 3-hydroxypropanal + H2O mechanism of enzyme reaction Limosilactobacillus reuteri
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.30 glycerol
-
 Pantoea agglomerans 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol
-
 Levilactobacillus brevis 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol
-
 Lactobacillus sp. 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol
-
 Clostridium butyricum 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol
-
 Lentilactobacillus buchneri 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol
-
 Limosilactobacillus reuteri 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol preferred substrate Klebsiella pneumoniae 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol preferred substrate Clostridium pasteurianum 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol preferred substrate Citrobacter freundii 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol glycerol fermentation Klebsiella pneumoniae 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol glycerol fermentation Citrobacter freundii 3-hydroxypropanal + H2O 3-hydroxypropionaldehyde ?
4.2.1.30 glycerol
-
 Klebsiella pneumoniae ?
-
 ?
4.2.1.30 glycerol
-
 Pantoea agglomerans ?
-
 ?
4.2.1.30 glycerol
-
 Clostridium pasteurianum ?
-
 ?
4.2.1.30 glycerol
-
 Levilactobacillus brevis ?
-
 ?
4.2.1.30 glycerol
-
 Lactobacillus sp. ?
-
 ?
4.2.1.30 glycerol
-
 Clostridium butyricum ?
-
 ?
4.2.1.30 glycerol
-
 Citrobacter freundii ?
-
 ?
4.2.1.30 glycerol
-
 Lentilactobacillus buchneri ?
-
 ?
4.2.1.30 glycerol
-
 Limosilactobacillus reuteri ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.30 hexamer alpha2,beta2,gamma2, 2 * 60433 + 2 * 21487 + 2 * 16121, calculation from sequence of amino acid Citrobacter freundii
4.2.1.30 hexamer alpha2,beta2,gamma2, 2 * 60813 + 2 * 19549 + 2 * 16722, calculation from sequence of amino acid Clostridium pasteurianum

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.30 5,6-Dimethylbenzimidazolylcobamide coenzyme required Klebsiella pneumoniae
4.2.1.30 5,6-Dimethylbenzimidazolylcobamide coenzyme required Pantoea agglomerans
4.2.1.30 5,6-Dimethylbenzimidazolylcobamide coenzyme required Clostridium pasteurianum
4.2.1.30 5,6-Dimethylbenzimidazolylcobamide coenzyme required Levilactobacillus brevis
4.2.1.30 5,6-Dimethylbenzimidazolylcobamide coenzyme required Lactobacillus sp.
4.2.1.30 5,6-Dimethylbenzimidazolylcobamide coenzyme required Citrobacter freundii
4.2.1.30 5,6-Dimethylbenzimidazolylcobamide coenzyme required Lentilactobacillus buchneri
4.2.1.30 5,6-Dimethylbenzimidazolylcobamide coenzyme required Limosilactobacillus reuteri