BRENDA - Enzyme Database

Aconitase

Pickworth Glusker, J.; The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 5, 413-439 (1971)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.3
1,10-phenanthroline
noncompetitive
Bacillus subtilis
4.2.1.3
1,2,3,4-tetracarboxycyclopentane
competitive
Sus scrofa
4.2.1.3
1,2,3-tricarboxycyclopentene-1
competitive
Sus scrofa
4.2.1.3
1,3,5-tricarboxypentane
competitive
Sus scrofa
4.2.1.3
2,2'-dipyridyl
noncompetitive
Bacillus subtilis
4.2.1.3
4-hydroxy-2-oxoglutarate
competitive
Sus scrofa
4.2.1.3
alpha-picolinic acid
noncompetitive
Bacillus subtilis
4.2.1.3
Fluorocitrate
-
Bos taurus
4.2.1.3
Fluorocitrate
linear competitive
Rattus norvegicus
4.2.1.3
Fluorocitrate
linear competitive
Sus scrofa
4.2.1.3
oxaloacetate
parabolic noncompetitive
Sus scrofa
4.2.1.3
Oxalomalate
competitive
Rattus norvegicus
4.2.1.3
Oxalomalate
competitive
Saccharomyces cerevisiae
4.2.1.3
Oxalomalate
competitive
Solanum tuberosum
4.2.1.3
Oxalomalate
competitive
Sus scrofa
4.2.1.3
Phthalic acid
competitive
Sus scrofa
4.2.1.3
pyromellitic acid
competitive
Sus scrofa
4.2.1.3
Quinaldic acid
noncompetitive
Bacillus subtilis
4.2.1.3
threo-Ls-isocitrate
competitive
Bos taurus
4.2.1.3
trans-aconitate
linear competitive
Sus scrofa
4.2.1.3
tricarballylate
linear competitive
Bos taurus
4.2.1.3
tricarballylate
-
Sus scrofa
4.2.1.3
trimellitic acid
competitive
Sus scrofa
4.2.1.3
trimesic acid
competitive
Sus scrofa
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
4.2.1.3
additional information
-
additional information
-
Bos taurus
4.2.1.3
additional information
-
additional information
-
Sus scrofa
4.2.1.3
0.007
-
cis-aconitate
liver enzyme
Bos taurus
4.2.1.3
0.009
-
cis-aconitate
-
Oryctolagus cuniculus
4.2.1.3
0.034
-
isocitrate
liver enzyme
Bos taurus
4.2.1.3
0.099
-
cis-aconitate
heart enzyme
Bos taurus
4.2.1.3
0.1
-
cis-aconitate
-
Sinapis alba
4.2.1.3
0.139
-
isocitrate
heart enzyme
Bos taurus
4.2.1.3
0.15
-
isocitrate
-
Sinapis alba
4.2.1.3
0.2
-
citrate
liver enzyme
Bos taurus
4.2.1.3
0.32
-
isocitrate
-
Oryctolagus cuniculus
4.2.1.3
0.58
-
isocitrate
-
Glycine max
4.2.1.3
0.9
-
citrate
-
Oryctolagus cuniculus
4.2.1.3
0.95
-
citrate
heart enzyme
Bos taurus
4.2.1.3
1.7
-
citrate
-
Bacillus subtilis
4.2.1.3
4
4.4
citrate
-
Sinapis alba
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.3
cytoplasm
-
Rattus norvegicus
5737
-
4.2.1.3
mitochondrion
particulate-bound mitochondrial enzyme, the soluble mitochondrial enzyme is released from the mitochondria by freezing and thawing
Rattus norvegicus
5739
-
4.2.1.3
mitochondrion
-
Bos taurus
5739
-
4.2.1.3
mitochondrion
-
Sus scrofa
5739
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.2.1.3
89000
-
equilibrium sedimentation
Sus scrofa
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.3
Aspergillus niger
-
-
-
4.2.1.3
Bacillus subtilis
-
-
-
4.2.1.3
Bos taurus
-
-
-
4.2.1.3
Glycine max
-
-
-
4.2.1.3
Oryctolagus cuniculus
-
-
-
4.2.1.3
Rattus norvegicus
-
3 aconitases
-
4.2.1.3
Rheum sp.
-
i.e. rhubarb
-
4.2.1.3
Saccharomyces cerevisiae
-
-
-
4.2.1.3
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
4.2.1.3
Sinapis alba
-
-
-
4.2.1.3
Solanum tuberosum
-
-
-
4.2.1.3
Sus scrofa
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
4.2.1.3
-
Aspergillus niger
4.2.1.3
-
Rattus norvegicus
4.2.1.3
-
Sinapis alba
4.2.1.3
-
Bos taurus
4.2.1.3
-
Sus scrofa
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.3
heart
-
Sus scrofa
-
4.2.1.3
heart
-
Bos taurus
-
4.2.1.3
leaf
-
Rheum sp.
-
4.2.1.3
liver
-
Oryctolagus cuniculus
-
4.2.1.3
liver
-
Bos taurus
-
4.2.1.3
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.3
cis-aconitate
-
33784
Sus scrofa
citrate
-
33784
Sus scrofa
r
4.2.1.3
cis-aconitate
-
33784
Bos taurus
citrate
-
33784
Bos taurus
r
4.2.1.3
cis-aconitate
-
33784
Rattus norvegicus
isocitrate
-
33784
Rattus norvegicus
-
4.2.1.3
cis-aconitate
-
33784
Sus scrofa
isocitrate
-
33784
Sus scrofa
r
4.2.1.3
cis-aconitate
-
33784
Bos taurus
isocitrate
-
33784
Bos taurus
r
4.2.1.3
citrate
-
33784
Rattus norvegicus
cis-aconitate
-
33784
Rattus norvegicus
-
4.2.1.3
citrate
-
33784
Sus scrofa
cis-aconitate
-
33784
Sus scrofa
r
4.2.1.3
citrate
-
33784
Bos taurus
cis-aconitate
-
33784
Bos taurus
r
4.2.1.3
citrate
-
33784
Rattus norvegicus
isocitrate
-
-
-
-
4.2.1.3
citrate
-
33784
Sus scrofa
isocitrate
-
33784
Sus scrofa
r
4.2.1.3
citrate
-
33784
Bos taurus
isocitrate
-
33784
Bos taurus
r
4.2.1.3
isocitrate
-
33784
Rattus norvegicus
citrate
-
-
-
-
4.2.1.3
isocitrate
-
33784
Sus scrofa
citrate
-
33784
Sus scrofa
r
4.2.1.3
isocitrate
-
33784
Bos taurus
citrate
-
33784
Bos taurus
r
4.2.1.3
isocitrate
-
33784
Sus scrofa
cis-aconitate
-
33784
Sus scrofa
r
4.2.1.3
isocitrate
-
33784
Bos taurus
cis-aconitate
-
33784
Bos taurus
r
Turnover Number [1/s]
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
4.2.1.3
additional information
-
additional information
-
Bacillus subtilis
4.2.1.3
additional information
-
additional information
-
Sus scrofa
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.2.1.3
5.8
-
mitochondrial isoenzyme
Rattus norvegicus
4.2.1.3
7.2
-
phosphate buffer
Rheum sp.
4.2.1.3
7.3
-
soluble enzyme
Rattus norvegicus
4.2.1.3
7.5
-
glycerophosphate buffer
Sus scrofa
4.2.1.3
7.7
-
phosphate buffer
Sus scrofa
4.2.1.3
8
8.5
-
Sinapis alba
4.2.1.3
8.1
-
N-ethylmorpholine buffer
Sus scrofa
4.2.1.3
8.6
-
veronal acetate buffer
Sus scrofa
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.3
1,10-phenanthroline
noncompetitive
Bacillus subtilis
4.2.1.3
1,2,3,4-tetracarboxycyclopentane
competitive
Sus scrofa
4.2.1.3
1,2,3-tricarboxycyclopentene-1
competitive
Sus scrofa
4.2.1.3
1,3,5-tricarboxypentane
competitive
Sus scrofa
4.2.1.3
2,2'-dipyridyl
noncompetitive
Bacillus subtilis
4.2.1.3
4-hydroxy-2-oxoglutarate
competitive
Sus scrofa
4.2.1.3
alpha-picolinic acid
noncompetitive
Bacillus subtilis
4.2.1.3
Fluorocitrate
-
Bos taurus
4.2.1.3
Fluorocitrate
linear competitive
Rattus norvegicus
4.2.1.3
Fluorocitrate
linear competitive
Sus scrofa
4.2.1.3
oxaloacetate
parabolic noncompetitive
Sus scrofa
4.2.1.3
Oxalomalate
competitive
Rattus norvegicus
4.2.1.3
Oxalomalate
competitive
Saccharomyces cerevisiae
4.2.1.3
Oxalomalate
competitive
Solanum tuberosum
4.2.1.3
Oxalomalate
competitive
Sus scrofa
4.2.1.3
Phthalic acid
competitive
Sus scrofa
4.2.1.3
pyromellitic acid
competitive
Sus scrofa
4.2.1.3
Quinaldic acid
noncompetitive
Bacillus subtilis
4.2.1.3
threo-Ls-isocitrate
competitive
Bos taurus
4.2.1.3
trans-aconitate
linear competitive
Sus scrofa
4.2.1.3
tricarballylate
linear competitive
Bos taurus
4.2.1.3
tricarballylate
-
Sus scrofa
4.2.1.3
trimellitic acid
competitive
Sus scrofa
4.2.1.3
trimesic acid
competitive
Sus scrofa
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
4.2.1.3
additional information
-
additional information
-
Bos taurus
4.2.1.3
additional information
-
additional information
-
Sus scrofa
4.2.1.3
0.007
-
cis-aconitate
liver enzyme
Bos taurus
4.2.1.3
0.009
-
cis-aconitate
-
Oryctolagus cuniculus
4.2.1.3
0.034
-
isocitrate
liver enzyme
Bos taurus
4.2.1.3
0.099
-
cis-aconitate
heart enzyme
Bos taurus
4.2.1.3
0.1
-
cis-aconitate
-
Sinapis alba
4.2.1.3
0.139
-
isocitrate
heart enzyme
Bos taurus
4.2.1.3
0.15
-
isocitrate
-
Sinapis alba
4.2.1.3
0.2
-
citrate
liver enzyme
Bos taurus
4.2.1.3
0.32
-
isocitrate
-
Oryctolagus cuniculus
4.2.1.3
0.58
-
isocitrate
-
Glycine max
4.2.1.3
0.9
-
citrate
-
Oryctolagus cuniculus
4.2.1.3
0.95
-
citrate
heart enzyme
Bos taurus
4.2.1.3
1.7
-
citrate
-
Bacillus subtilis
4.2.1.3
4
4.4
citrate
-
Sinapis alba
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.3
cytoplasm
-
Rattus norvegicus
5737
-
4.2.1.3
mitochondrion
particulate-bound mitochondrial enzyme, the soluble mitochondrial enzyme is released from the mitochondria by freezing and thawing
Rattus norvegicus
5739
-
4.2.1.3
mitochondrion
-
Bos taurus
5739
-
4.2.1.3
mitochondrion
-
Sus scrofa
5739
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.2.1.3
89000
-
equilibrium sedimentation
Sus scrofa
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.1.3
-
Aspergillus niger
4.2.1.3
-
Rattus norvegicus
4.2.1.3
-
Sinapis alba
4.2.1.3
-
Bos taurus
4.2.1.3
-
Sus scrofa
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.3
heart
-
Sus scrofa
-
4.2.1.3
heart
-
Bos taurus
-
4.2.1.3
leaf
-
Rheum sp.
-
4.2.1.3
liver
-
Oryctolagus cuniculus
-
4.2.1.3
liver
-
Bos taurus
-
4.2.1.3
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.3
cis-aconitate
-
33784
Sus scrofa
citrate
-
33784
Sus scrofa
r
4.2.1.3
cis-aconitate
-
33784
Bos taurus
citrate
-
33784
Bos taurus
r
4.2.1.3
cis-aconitate
-
33784
Rattus norvegicus
isocitrate
-
33784
Rattus norvegicus
-
4.2.1.3
cis-aconitate
-
33784
Sus scrofa
isocitrate
-
33784
Sus scrofa
r
4.2.1.3
cis-aconitate
-
33784
Bos taurus
isocitrate
-
33784
Bos taurus
r
4.2.1.3
citrate
-
33784
Rattus norvegicus
cis-aconitate
-
33784
Rattus norvegicus
-
4.2.1.3
citrate
-
33784
Sus scrofa
cis-aconitate
-
33784
Sus scrofa
r
4.2.1.3
citrate
-
33784
Bos taurus
cis-aconitate
-
33784
Bos taurus
r
4.2.1.3
citrate
-
33784
Rattus norvegicus
isocitrate
-
-
-
-
4.2.1.3
citrate
-
33784
Sus scrofa
isocitrate
-
33784
Sus scrofa
r
4.2.1.3
citrate
-
33784
Bos taurus
isocitrate
-
33784
Bos taurus
r
4.2.1.3
isocitrate
-
33784
Rattus norvegicus
citrate
-
-
-
-
4.2.1.3
isocitrate
-
33784
Sus scrofa
citrate
-
33784
Sus scrofa
r
4.2.1.3
isocitrate
-
33784
Bos taurus
citrate
-
33784
Bos taurus
r
4.2.1.3
isocitrate
-
33784
Sus scrofa
cis-aconitate
-
33784
Sus scrofa
r
4.2.1.3
isocitrate
-
33784
Bos taurus
cis-aconitate
-
33784
Bos taurus
r
Turnover Number [1/s] (protein specific)
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
4.2.1.3
additional information
-
additional information
-
Bacillus subtilis
4.2.1.3
additional information
-
additional information
-
Sus scrofa
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.2.1.3
5.8
-
mitochondrial isoenzyme
Rattus norvegicus
4.2.1.3
7.2
-
phosphate buffer
Rheum sp.
4.2.1.3
7.3
-
soluble enzyme
Rattus norvegicus
4.2.1.3
7.5
-
glycerophosphate buffer
Sus scrofa
4.2.1.3
7.7
-
phosphate buffer
Sus scrofa
4.2.1.3
8
8.5
-
Sinapis alba
4.2.1.3
8.1
-
N-ethylmorpholine buffer
Sus scrofa
4.2.1.3
8.6
-
veronal acetate buffer
Sus scrofa