EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.2.1.1 | H200T | complex effect on the catalytic and inhibitor-binding properties | Homo sapiens |
4.2.1.1 | H67N | complex effect on the catalytic and inhibitor-binding properties | Homo sapiens |
4.2.1.1 | V62H/H67N/H200T | complex effect on the catalytic and inhibitor-binding properties | Homo sapiens |
4.2.1.1 | V62N | complex effect on the catalytic and inhibitor-binding properties | Homo sapiens |
4.2.1.1 | V62N/H67N | complex effect on the catalytic and inhibitor-binding properties | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.1 | 4-S-isobutylamino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | binds 800 times more strongly to carbonic anhydrase II than to carbonic anhydrase I | Homo sapiens | |
4.2.1.1 | I- | inhibits 4-nitrophenyl acetate hydrolase activity | Homo sapiens | |
4.2.1.1 | SCN- | inhibits 4-nitrophenyl acetate hydrolase activity | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.1 | 0.31 | - |
CO2 | pH 8.95, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
4.2.1.1 | 2.3 | - |
CO2 | pH 8.98, TAPS buffer, carbonic anhydrase I mutant V62N,H67N, H200T | Homo sapiens | |
4.2.1.1 | 2.4 | - |
CO2 | pH 7.21, 1-methylimidazole buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
4.2.1.1 | 2.4 | - |
CO2 | pH 8.98, TAPS buffer, carbonic anhydrase I mutant H67B | Homo sapiens | |
4.2.1.1 | 2.8 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant N62V | Homo sapiens | |
4.2.1.1 | 3.5 | - |
CO2 | pH 8.98, TAPS buffer, carbonic anhydrase I mutant V62N | Homo sapiens | |
4.2.1.1 | 3.6 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
4.2.1.1 | 3.6 | - |
CO2 | pH 7.21, 1-methylimidazole buffer, wild-type carbonic anhydrase I | Homo sapiens | |
4.2.1.1 | 3.9 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant T200H | Homo sapiens | |
4.2.1.1 | 4 | - |
CO2 | pH 8.88, TAPS buffer, carbonic anhydrase I mutant V62N,H67N | Homo sapiens | |
4.2.1.1 | 5.3 | - |
CO2 | pH 8.77, 1,2-dimethylimidazole buffer, wild-type carbonic anhydrase I | Homo sapiens | |
4.2.1.1 | 6.6 | - |
CO2 | pH 8.75, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
4.2.1.1 | 7.1 | - |
CO2 | pH 8.95, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant V62N | Homo sapiens | |
4.2.1.1 | 7.5 | - |
CO2 | pH 7.23, 1-methylimidazolebuffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
4.2.1.1 | 8.8 | - |
CO2 | pH 8.7, 1,2-dimethylimidazole buffer, carbonic anhydrase II | Homo sapiens | |
4.2.1.1 | 9.4 | - |
CO2 | pH 8.72, 1,2-dimethyimidazole buffer, carbonic anhydrase I mutant V62N,H67N | Homo sapiens | |
4.2.1.1 | 9.7 | - |
CO2 | pH 8.9, TAPS buffer, carbonic anhydrase II | Homo sapiens | |
4.2.1.1 | 10 | - |
CO2 | pH 8.95, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
4.2.1.1 | 14 | - |
CO2 | pH 8.75, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
4.2.1.1 | 14 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant N67HV | Homo sapiens | |
4.2.1.1 | 15 | - |
CO2 | pH 7.23, 1-methylimidazole buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
4.2.1.1 | 46 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
4.2.1.1 | 69 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant V62N | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.1 | Homo sapiens | - |
wild-type carbonic anhydrase I and active-site mutants V62N, H67N, H200T, double-mutant V62N,H67N, and triple-mutant V62H,H67N,H200T. Wild-type carbonic anhydrase II and active site mutant enzymes N62V, N67H and T200H | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.1 | CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
? | |
4.2.1.1 | additional information | esterase activity with p-nitrophenyl acetate | Homo sapiens | ? | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.1 | 85 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
4.2.1.1 | 117 | - |
CO2 | pH 6.3, MES buffer, wild-type carbonic anhydrase I | Homo sapiens | |
4.2.1.1 | 217 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant V62N | Homo sapiens | |
4.2.1.1 | 217 | - |
CO2 | pH 6.3, MES buffer | Homo sapiens | |
4.2.1.1 | 233 | - |
CO2 | pH 8.88, TAPS buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
4.2.1.1 | 250 | - |
CO2 | pH 6.28, MES buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
4.2.1.1 | 433 | - |
CO2 | pH 8.8, TAPS buffer, wild-type carbonic anhydrase I | Homo sapiens | |
4.2.1.1 | 800 | - |
CO2 | pH 7.21, 1-methylimidazole buffer, wild-type carbonic anhydrase I | Homo sapiens | |
4.2.1.1 | 883 | - |
CO2 | pH 7.23, 1-methylimidazole buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
4.2.1.1 | 1180 | - |
CO2 | pH 8.98, TAPS buffer, carbonic anhydrase I mutant V62N and carbonic anhydrase I mutant H67N | Homo sapiens | |
4.2.1.1 | 1380 | - |
CO2 | pH 7.21, 1-methylimidazole buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
4.2.1.1 | 1400 | - |
CO2 | pH 8.98, TAPS buffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
4.2.1.1 | 1470 | - |
CO2 | pH 8.88, TAPS buffer, carbonic anhydrase I mutant V62N,H67N | Homo sapiens | |
4.2.1.1 | 2000 | - |
CO2 | pH 8.95, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant V62N | Homo sapiens | |
4.2.1.1 | 2830 | - |
CO2 | pH 8.75, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant H67N | Homo sapiens | |
4.2.1.1 | 3500 | - |
CO2 | pH 8.77, 1,2-dimethylimidazole buffer, wild-type carbonic anhydrase I | Homo sapiens | |
4.2.1.1 | 3500 | - |
CO2 | pH 8.72, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant V62B, H67B | Homo sapiens | |
4.2.1.1 | 3670 | - |
CO2 | pH 7.23, 1-methylimidazolebuffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
4.2.1.1 | 4000 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant T200H | Homo sapiens | |
4.2.1.1 | 5500 | - |
CO2 | pH 8.95, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant H200T | Homo sapiens | |
4.2.1.1 | 8170 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant N62V | Homo sapiens | |
4.2.1.1 | 8500 | - |
CO2 | pH 8.75, 1,2-dimethylimidazole buffer, carbonic anhydrase I mutant V62N,H67N,H200T | Homo sapiens | |
4.2.1.1 | 15200 | - |
CO2 | pH 8.7, 1,2-dimethylimidazole buffer, carbonic anhydrase II | Homo sapiens | |
4.2.1.1 | 16700 | - |
CO2 | pH 8.9, TAPS buffer, carbonic anhydrase II | Homo sapiens | |
4.2.1.1 | 28300 | - |
CO2 | pH 8.94, 1,2-dimethylimidazole buffer, carbonic anhydrase II mutant N67H | Homo sapiens |