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Literature summary extracted from

  • Morollo, A.A.; Bauerle, R.
    Characterization of composite aminodeoxyisochorismate synthase and aminodeoxyisochorismate lyase activities of anthranilate synthase (1993), Proc. Natl. Acad. Sci. USA, 90, 9983-9987.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.27 L-Trp
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.86 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
4.1.3.27 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.3.27 chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate trans-6-amino-5-[(2-carboxyethenyl)-oxy]-1,3-cyclohexadiene-1-carboxylic acid is an enzyme-bound inhibitor Salmonella enterica subsp. enterica serovar Typhimurium
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.86 chorismate + L-glutamine (2S)-2-amino-4-deoxychorismate is formed by a reversible, Mg2+-dependent ADIC synthase activity of anthranilate synthase (EC 4.1.3.27) that can be functionally uncoupled from a Mg2+-dependent ADIC lyase activity of the enzyme by single amino acid substitutions in the TrpE subunit of the anthranilate synthase complex of Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium (2S)-2-amino-4-deoxychorismate + L-glutamate
-
 ?
4.1.3.27 chorismate + L-Gln
-
 Salmonella enterica subsp. enterica serovar Typhimurium anthranilate + pyruvate + L-glutamate
-
 ?