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Literature summary extracted from

  • Robb, F.; Hutchinson, M.A.; Belser, W.L.
    Anthranilate synthetase. Some physical and kinetic properties of the enzyme from Serratia marcescens (1971), J. Biol. Chem., 246, 6908-6912.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.27 L-Trp feedback inhibition Serratia marcescens
4.1.3.27 PCMB
-
 Serratia marcescens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.3.27 0.0031
-
 chorismate
-
 Serratia marcescens
4.1.3.27 0.33
-
 Gln
-
 Serratia marcescens
4.1.3.27 10
-
 NH4+
-
 Serratia marcescens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.3.27 140000
-
 sucrose density gradient centrifugation Serratia marcescens
4.1.3.27 150000
-
 gel filtration Serratia marcescens

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.27 Serratia marcescens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.27
-
 Serratia marcescens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.3.27 4.5
-
-
 Serratia marcescens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.27 chorismate + L-Gln
-
 Serratia marcescens anthranilate + pyruvate + L-glutamate
-
 ?
4.1.3.27 chorismate + NH4+
-
 Serratia marcescens ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.3.27 7.6
-
 Gln-dependent activity Serratia marcescens
4.1.3.27 8.5
-
 above pH 8.5 Serratia marcescens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.1.3.27 6 8 about 75% of maximal activity, Gln-dependent activity Serratia marcescens