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Literature summary extracted from

  • Hoyt, J.C.; Robertson, E.F.; Berlyn, K.A.; Reeves, H.C.
    Escherichia coli isocitrate lyase: properties and comparisons (1988), Biochim. Biophys. Acta, 966, 30-35.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.1 3-nitropropionate 50% inhibition at 0.04 mM Escherichia coli
4.1.3.1 Ca2+
-
Escherichia coli
4.1.3.1 Dithionitrobenzoate
-
Escherichia coli
4.1.3.1 glycolate 50% inhibition at 5 mM Escherichia coli
4.1.3.1 HgCl2 100% inhibition at 0.01 mM Escherichia coli
4.1.3.1 Hydroxymalonate 50% inhibition at 0.5 mM Escherichia coli
4.1.3.1 KCl
-
Escherichia coli
4.1.3.1 malonate
-
Escherichia coli
4.1.3.1 methylmalonate 50% inhibition at 15 mM Escherichia coli
4.1.3.1 NaCl
-
Escherichia coli
4.1.3.1 oxalate
-
Escherichia coli
4.1.3.1 succinate
-
Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.3.1 Co2+ no activity in absence of exogenous cation Escherichia coli
4.1.3.1 Co2+ Co2+ 17% as effective as Mg2+ Escherichia coli
4.1.3.1 Mg2+ no activity in absence of exogenous cation, Mg2+ most effective Escherichia coli
4.1.3.1 Mn2+ no activity in absence of exogenous cation Escherichia coli
4.1.3.1 Mn2+ Mn2+ 54% as effective as Mg2+ Escherichia coli
4.1.3.1 Ni2+ no activity in absence of exogenous cation, Ni2+ 7% as effective as Mg2+ Escherichia coli
4.1.3.1 Sr2+ no activity in absence of exogenous cation, Sr2+ 3% as effective as Mg2+ Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.3.1 isocitrate Escherichia coli glyoxylate cycle ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.1 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.1
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.1 isocitrate
-
Escherichia coli succinate + glyoxylate
-
r
4.1.3.1 isocitrate glyoxylate cycle Escherichia coli ?
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.3.1 0.04
-
3-nitropropionate
-
Escherichia coli
4.1.3.1 0.5
-
Hydroxymalonate
-
Escherichia coli
4.1.3.1 15
-
methylmalonate
-
Escherichia coli