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Literature summary extracted from

  • Najjar, V.A
    Phosphoglucomutase (1962), The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. ), 6, 161-178.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.4.2.2 alpha-D-glucose 1,6-diphosphate
-
Saccharomyces cerevisiae
5.4.2.2 alpha-D-glucose 1,6-diphosphate the beta-form is inactive Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.2.2 Ag+
-
Oryctolagus cuniculus
5.4.2.2 Cu2+
-
Oryctolagus cuniculus
5.4.2.2 F-
-
Oryctolagus cuniculus
5.4.2.2 Hg2+
-
Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.2.2 Glucose 6-phosphate Oryctolagus cuniculus synthesis of glucose 1-phosphate for the formation of UDPglucose ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
5.4.2.2 Oryctolagus cuniculus
-
rabbit
-
5.4.2.2 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.2.2
-
Oryctolagus cuniculus

Reaction

EC Number Reaction Comment Organism Reaction ID
5.4.2.2 alpha-D-glucose 1-phosphate = D-glucose 6-phosphate in the forward reaction a phosphate from the enzyme is transferred to C-6 of glucose 1-phosphate which results in a dephosphoenzyme intermediate. In the second step phosphate from the C-1 of glucose is transferred to the enzyme for its regeneration. The reverse reaction proceeds via a similar mechanism Oryctolagus cuniculus

Storage Stability

EC Number Storage Stability Organism
5.4.2.2 4-6°C, 0.05 M acetate buffer, pH 5.0, crystalline enzyme form, many months stable Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.2.2 alpha-D-glucose 1-phosphate
-
Saccharomyces cerevisiae alpha-D-glucose 6-phosphate
-
?
5.4.2.2 alpha-D-glucose 1-phosphate the beta-form is inactive Oryctolagus cuniculus alpha-D-glucose 6-phosphate
-
?
5.4.2.2 Glucose 6-phosphate
-
Oryctolagus cuniculus Glucose 1-phosphate
-
?
5.4.2.2 Glucose 6-phosphate synthesis of glucose 1-phosphate for the formation of UDPglucose Oryctolagus cuniculus ?
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.4.2.2 additional information
-
additional information
-
Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.4.2.2 7.5
-
purified enzyme in presence of Mg2+ Oryctolagus cuniculus
5.4.2.2 7.5 9.2 crude enzyme form Oryctolagus cuniculus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
5.4.2.2 8
-
unstable above Oryctolagus cuniculus