Literature summary extracted from

Furneaux, R.H.; Schramm, V.L.; Tyler, P.C.
Transition state analogue inhibitors of protozoan nucleoside hydrolases (1999), Bioorg. Med. Chem., 7, 2599-2606.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.2.2.1	(1S)-(1-aminonaphthalen-4-yl)-1,4-dideoxy-1,4-imino-D-ribitol	-	Trypanosoma brucei
3.2.2.1	(1S)-1-(2,3-diamino-5-pyridyl)-1,4-dideoxy-1,4-imino-D-ribitol	-	Trypanosoma brucei
3.2.2.1	(1S)-1-(3,4-diaminophenyl)-1,4-dideoxy-1,4-imino-D-ribitol	-	Trypanosoma brucei
3.2.2.1	(1S)-1-(4-aminomethyl)phenyl-1,4-dideoxy-1,4-imino-D-ribitol	-	Trypanosoma brucei
3.2.2.1	(1S)-1-(4-cyanophenyl)1,4-dideoxy-1,4-imino-D-ribitol	-	Trypanosoma brucei
3.2.2.1	1,2,5-trideoxy-1-(guanin-9-yl)-2,5-imino-D-allitol	-	Trypanosoma brucei
3.2.2.1	1,2,5-trideoxy-1-(hypoxanthin-9-yl)-2,5-imino-D-alitol	-	Trypanosoma brucei
3.2.2.1	1-(5-carboxamido-2-pyridyl)-1,2,5-trideoxy-2,5-imino-D-allitol	-	Trypanosoma brucei
3.2.2.1	1-(adenin-9-yl)-1,2,5-trideoxy-2,5-imino-D-allitol	-	Trypanosoma brucei
3.2.2.1	iminoribitols	poorly inhibited by free or substituted iminoribitols	Trypanosoma brucei
3.2.2.1	additional information	transition state analogue inhibitors of protozoan nucleoside hydrolases	Trypanosoma brucei

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.2.2.1	Trypanosoma brucei	-	brucei	-

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Release 2023.1 (January 2023)