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Literature summary extracted from
- Biosynthesis of thromboxanes in human platelets. I. Characterization and assay of thromboxane synthetase (1977), Biochem. Biophys. Res. Commun., 74, 1432-1440.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.5 | 9,11(Epoxymethano) prostanoic acid | - |
Homo sapiens |  |
| 5.3.99.5 | 9alpha,11alpha-Methanoepoxy-15(S)-hydroxyprosta-5(cis)-13(trans)-dienoic acid | weak | Homo sapiens | |
| 5.3.99.5 | additional information | the enzyme is not affected by nonsteroidal antiinflammatory agents | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.3.99.5 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.5 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.3.99.5 | platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.5 | Prostaglandin H2 | i.e. PGH2 | Homo sapiens | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | thromboxane A2 is an intermediate | ? | |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.3.99.5 | 5 | 8.5 | very little pH-dependence between pH 5-8.5, above pH 9.0 the reaction is significantly depressed | Homo sapiens |
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Release 2023.1 (January 2023)
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