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Literature summary extracted from

  • Hammarstroem, S.; Diczfalusy, U.
    Inhibition and properties of thromboxane synthetase (1979), Adv. Inflamm. Res., 1, 431-438.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.5 1(omega-Carboxylalkyl)imidazoles very potent Homo sapiens
5.3.99.5 1-Methyl imidazole
-
 Homo sapiens
5.3.99.5 2-Isopropyl-3-nicotinylindole
-
 Homo sapiens
5.3.99.5 4-{2-[(4-chlorophenyl)methyl]-3-phenylpropanoyl}phenyl hydrogen benzylphosphonate i.e. N-0164 Homo sapiens
5.3.99.5 9,11(Epoxymethano) prostanoic acid
-
 Homo sapiens
5.3.99.5 9,11-Azo-15-hydroxyprosta-5,13-dienoic acid
-
 Homo sapiens
5.3.99.5 9,11-Azoprosta-5,13-dienoic acid
-
 Homo sapiens
5.3.99.5 9,11-Epoxymethano-15-hydroxy-prosta-5,13-dienoic acid
-
 Homo sapiens
5.3.99.5 Benzydamine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.5 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.99.5 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.5 platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.5 2 prostaglandin G2 + H2O i.e. PGG2 Homo sapiens 15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
 ?
5.3.99.5 prostaglandin H1
-
 Homo sapiens 12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1 thromboxane B1 is scarcely detectable, the major product is 12(L)-hydroxy-8,10-heptadecadienoic acid ?
5.3.99.5 Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid the thromboxane A2 that is formed by the enzyme is transformed to thromboxane B2 ?
5.3.99.5 Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid + malondialdehyde ?
5.3.99.5 Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1 ?