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Literature summary extracted from

  • Haurand, M.; Ullrich, V.
    Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme (1985), J. Biol. Chem., 260, 15059-15067.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.5 microsome
-
Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.5 58800
-
x * 58800, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.99.5
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.5 platelet
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.3.99.5 24.1
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.5 Prostaglandin H2 i.e. PGH2 Homo sapiens thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
?

Subunits

EC Number Subunits Comment Organism
5.3.99.5 ? x * 58800, SDS-PAGE Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.3.99.5 27.1
-
prostaglandin H2
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.3.99.5 heme the heme-thiolate group of the enzyme is required to split and activate the endoperoxide bond of prostaglandin H2 Homo sapiens
5.3.99.5 heme 1 heme per polypeptide chain of MW 58800 Homo sapiens