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Literature summary extracted from
- Products, kinetics, and substrate specificity of homogeneous thromboxane synthase from human platelets: development of a novel enzyme assay (1987), Arch. Biochem. Biophys., 254, 124-135.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.99.5 | 0.022 | - |
prostaglandin H2 | - |
Homo sapiens |  |
| 5.3.99.5 | 0.023 | - |
prostaglandin G2 | prostaglandin H3 | Homo sapiens | |
| 5.3.99.5 | 0.024 | - |
Prostaglandin H1 | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.5 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.3.99.5 | platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.5 | 2 prostaglandin G2 + H2O | i.e. PGG2 | Homo sapiens | 15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid | - |
? | |
| 5.3.99.5 | 2 prostaglandin H3 + H2O | - |
Homo sapiens | thromboxane B3 + 12(L)-hydroxy-5,8,10,14-heptadecatetraenoic acid + malondialdehyde | the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1. Thromboxane A2 is fully transformed to thromboxane B2 | ? | |
| 5.3.99.5 | prostaglandin H1 | - |
Homo sapiens | 12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1 | - |
? | |
| 5.3.99.5 | Prostaglandin H2 | i.e. PGH2 | Homo sapiens | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | the thromboxane A2 that is formed by the enzyme is transformed to thromboxane B2 | ? | |
| 5.3.99.5 | Prostaglandin H2 | i.e. PGH2 | Homo sapiens | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | + malondialdehyde | ? | |
| 5.3.99.5 | Prostaglandin H2 | i.e. PGH2 | Homo sapiens | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1 | ? | |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.3.99.5 | 20 | 37 | activity at 37°C is not significantly higher than at 20°C | Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.99.5 | 20.4 | - |
prostaglandin H3 | - |
Homo sapiens | |
| 5.3.99.5 | 26.7 | - |
prostaglandin H2 | - |
Homo sapiens | |
| 5.3.99.5 | 28.2 | - |
prostaglandin G2 | - |
Homo sapiens | |
| 5.3.99.5 | 59.4 | - |
prostaglandin H3 | - |
Homo sapiens | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.3.99.5 | 7.4 | - |
broad | Homo sapiens |
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