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Literature summary extracted from

  • Moncrief, J.S.; Obisco, R.; Barroso, L.A.; Kling, J.J.; Wright, R.L.; van Tassell, R.L.; Lyerly, D.M.; Wilkins, T.D.
    The enterotoxin of Bacteroides fragilis is a metalloprotease (1995), Infect. Immun., 63, 175-181.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.74
-
 Bacteroides fragilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.74 1,10-phenanthroline
-
 Bacteroides fragilis
3.4.24.74 2,2'-dipyridyl
-
 Bacteroides fragilis
3.4.24.74 Alpha-macroglobulin moderate inhibitor Bacteroides fragilis
3.4.24.74 diethyldicarbonate moderate inhibitor Bacteroides fragilis
3.4.24.74 dithiothreitol
-
 Bacteroides fragilis
3.4.24.74 EDTA
-
 Bacteroides fragilis
3.4.24.74 additional information not inhibitory are phenylmethylsulfonylfluoride, 4-(2-aminoethyl)-benzenesulfonylfluoride, tosylamide-2-phenylethyl chloromethylketone, tosyl-Lys chloromethylketone Bacteroides fragilis
3.4.24.74 thimerosal i.e. sodium ethylmercurithiosalicylate Bacteroides fragilis
3.4.24.74 Zincov
-
 Bacteroides fragilis
3.4.24.74 Zn2+ 10 mM, slightly inhibitory Bacteroides fragilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.74 extracellular
-
 Bacteroides fragilis
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.74 Zn2+ metalloprotease, 1 gatom of Zn2+ per mol of enzyme Bacteroides fragilis

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.74 Bacteroides fragilis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.74 culture filtrate
-
 Bacteroides fragilis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.74 Actin + H2O initial cleavage at Gly-Met, followed by Thr-Leu Bacteroides fragilis Fragements of actin
-
 ?
3.4.24.74 Azocoll + H2O
-
 Bacteroides fragilis Fragements of azocoll
-
 ?
3.4.24.74 Fibrinogen + H2O hydrolysis to a lesser degree than other substrates Bacteroides fragilis Fragements of fibrinogen
-
 ?
3.4.24.74 Fragilysin + H2O autodigestion Bacteroides fragilis Fragements of fragilysisn
-
 ?
3.4.24.74 Gelatin + H2O
-
 Bacteroides fragilis Fragements of gelatin
-
 ?
3.4.24.74 Tropomyosin + H2O hydrolysis to a lesser degree than other substrates Bacteroides fragilis Fragements of tropomyosin
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.74 37
-
-
 Bacteroides fragilis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.74 6.5
-
-
 Bacteroides fragilis