Literature summary extracted from

Duckworth, W.C.; Garcia, J.V.; Liepnieks, J.J.; Hamel, F.G.; Hermodson, M.A.; Frank, B.H.; Rosner, M.R.
Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites (1989), Biochemistry, 28, 2471-2477.

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.56	Drosophila melanogaster	-	-	-
3.4.24.56	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.56	Insulin + H2O	porcine	Rattus norvegicus	Hydrolyzed insulin	-	?
3.4.24.56	Insulin + H2O	Drosophila and rat enzyme cleave the A-chain of intact insulin between residues A13-A14 and A14-A15	Drosophila melanogaster	Hydrolyzed insulin	-	?
3.4.24.56	Insulin + H2O	Drosophila and rat enzyme cleave the A-chain of intact insulin between residues A13-A14 and A14-A15	Rattus norvegicus	Hydrolyzed insulin	-	?
3.4.24.56	Insulin + H2O	the Drosophila enzyme cleaves the B-chain of intact insulin at B10-B11, B14-B15, B16-B17 and B25-B26	Drosophila melanogaster	Hydrolyzed insulin	-	?

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Release 2023.1 (January 2023)